The average median S.D. and PEV reduction after applying different normalization methods compared with raw data. The average median S.D. and PEV reduction.

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The average median S.D. and PEV reduction after applying different normalization methods compared with raw data. The average median S.D. and PEV reduction after applying different normalization methods compared with raw data. The largest reductions were observed with the methods Regr and RegrRun, and the smallest reduction was observed with the Spike method. Intermediate reductions were observed with the remaining seven methods. The error bars display 1 standard error of the mean. Kim Kultima et al. Mol Cell Proteomics 2009;8:2285-2295 © 2009 by The American Society for Biochemistry and Molecular Biology, Inc.