Alex Kentsis, A. Thomas Look  Cell Stem Cell 

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Distinct and Dynamic Requirements for mTOR Signaling in Hematopoiesis and Leukemogenesis  Alex Kentsis, A. Thomas Look  Cell Stem Cell  Volume 11, Issue 3, Pages 281-282 (September 2012) DOI: 10.1016/j.stem.2012.08.007 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 Contribution of mTORC1 and mTORC2 Signaling to Normal Hematopoiesis and PTEN Loss-Induced Leukemogenesis PTEN negatively regulates PI3K-AKT signaling, which is mediated in part by mTORC1 and mTORC2, multiprotein complexes containing the mTOR kinase and specific substrate recruitment factors Raptor and Rictor, respectively. Cell Stem Cell 2012 11, 281-282DOI: (10.1016/j.stem.2012.08.007) Copyright © 2012 Elsevier Inc. Terms and Conditions

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