Stem Cells: All that Is Solid Melts into Air

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Stem Cells: All that Is Solid Melts into Air Maartje van der Heijden, Louis Vermeulen  Cell Stem Cell  Volume 21, Issue 1, Pages 5-7 (July 2017) DOI: 10.1016/j.stem.2017.06.009 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Dynamic Chromatin Remodeling Underlies Intestinal Plasticity Left: during homeostasis, ISCs and enterocyte progenitors display similar chromatin accessibility profiles, which are clearly distinct from the secretory (progenitor) cells. Right: following ISC loss, precursors of both lineages can rapidly repopulate the ISC compartment, and secretory lineage committed cells display dramatic chromatin remodeling to again adopt an ISC profile. Cell Stem Cell 2017 21, 5-7DOI: (10.1016/j.stem.2017.06.009) Copyright © 2017 Elsevier Inc. Terms and Conditions

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