Statins: Old drugs as new therapy for liver diseases? Elisa Pose, Jonel Trebicka, Rajeshwar P Mookerjee, Paolo Angeli, Pere Ginès  Journal of Hepatology  Volume 70, Issue 1, Pages 194-202 (January 2019) DOI: 10.1016/j.jhep.2018.07.019 Copyright © 2018 European Association for the Study of the Liver Terms and Conditions

Fig. 1 Pleiotropic effects of statins on small GTPases in the liver. The decrease in activation of small GPTases RhoA and Ras in hepatic stellate cells and liver sinusoidal endothelial cells leads to changes in the subsequent signalling pathways, which results in less fibrogenesis, less hepatic inflammation and lower portal pressure. Additional statins have direct effects on hepatocyte growth and proliferation signals and thereby might abrogate the development of hepatocellular carcinoma. Journal of Hepatology 2019 70, 194-202DOI: (10.1016/j.jhep.2018.07.019) Copyright © 2018 European Association for the Study of the Liver Terms and Conditions