Non-invasive assessment of fluid responsiveness using CNAP™ technology is interchangeable with invasive arterial measurements during major open abdominal.

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Non-invasive assessment of fluid responsiveness using CNAP™ technology is interchangeable with invasive arterial measurements during major open abdominal surgery J Renner, M Gruenewald, M Hill, L Mangelsdorff, H Aselmann, C Ilies, M Steinfath, O Broch British Journal of Anaesthesia Volume 118, Issue 1, Pages 58-67 (January 2017) DOI: 10.1093/bja/aew399 Copyright © 2017 The Author(s) Terms and Conditions

Fig 1 Flow of participants. PLR, passive leg raising. Responders, increase in stroke volume index measured by transpulmonary thermodilution ≥15%. British Journal of Anaesthesia 2017 118, 58-67DOI: (10.1093/bja/aew399) Copyright © 2017 The Author(s) Terms and Conditions

Fig 2 Correlation between pulse pressure variation (PPV) before volume-loading manoeuvre and percentage change in stroke volume index measured by transpulmonary thermodilution (ΔSVITPTD; n=85). The grey rectangle indicates the upper and lower limits of the uncertainty zone, the grey zone. British Journal of Anaesthesia 2017 118, 58-67DOI: (10.1093/bja/aew399) Copyright © 2017 The Author(s) Terms and Conditions

Fig 3 Box plots and individual values of pulse pressure variation obtained with the PiCCO system (PPVPiCCO) and with the CNAP device (PPVCNAP) in responders (Rs) and non-responders (NRs) before volume-loading manoeuvres (passive leg raising and first fluid bolus of crystalloid). The dashed line indicates the calculated threshold value of PPVCNAP (9%) and of PPVPiCCO (13%). The ‘grey zone’ is indicated with the grey rectangle (PPVCNAP, 7–10%; PPVPiCCO, 10–13%). British Journal of Anaesthesia 2017 118, 58-67DOI: (10.1093/bja/aew399) Copyright © 2017 The Author(s) Terms and Conditions

Fig 4 Receiver operating characteristic (ROC) curves showing the ability of PPVPiCCO and PPVCNAP to predict fluid responsiveness to different volume-loading manoeuvres. (A) Passive leg raising. (B) Fluid resuscitation in the operating room. (C) Summary of both volume challenges. British Journal of Anaesthesia 2017 118, 58-67DOI: (10.1093/bja/aew399) Copyright © 2017 The Author(s) Terms and Conditions