ZMP: A Master Regulator of One-Carbon Metabolism

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ZMP: A Master Regulator of One-Carbon Metabolism Gregory S. Ducker, Joshua D. Rabinowitz Molecular Cell Volume 57, Issue 2, Pages 203-204 (January 2015) DOI: 10.1016/j.molcel.2015.01.012 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 ZMP Regulates Expression of Tetrahydrofolate Genes The purine intermediate ZMP (highlighted in pink) is a positive regulator of expression of tetrahydrofolate genes involved in one-carbon metabolism. ZMP can also be produced from ATP via the histidine biosynthesis pathway. A conserved riboswitch is activated by ZMP binding, leading to expression of metabolic genes highlighted in pink. GlyA (glycine hydroxymethyltransferase), FolD (5,10-methylene-tetrahydrofolate dehydrogenase/5,10-methylene-tetrahydrofolate cyclohydrolase), Fhs (formate tetrahydrofolate ligase), PurH (AICAR formyltransferase/IMP cyclohydrolase). Molecular Cell 2015 57, 203-204DOI: (10.1016/j.molcel.2015.01.012) Copyright © 2015 Elsevier Inc. Terms and Conditions