The role of HMGB1/TLR4 in tendon disease.

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Presentation transcript:

The role of HMGB1/TLR4 in tendon disease. The role of HMGB1/TLR4 in tendon disease. Schematic diagram illustrating the manner in which early tendinopathy may arise due tenocyte HMGB1 expression/release. An increased stress that a tendon cell experiences results in the release of HMGB1 from tenocytes, which interacts to drive a proinflammatory phenotype with aberrant tendon remodelling towards an early tendinopathic process. HMGB1, high-mobility group protein B1; IL, interleukin. Moeed Akbar et al. RMD Open 2017;3:e000456 Copyright © BMJ Publishing Group & EULAR. All rights reserved.