Volume 75, Issue 9, Pages 880-881 (May 2009) Phosphate: despite advances in research, the benefits to patients remain limited  Marc E. De Broe  Kidney International  Volume 75, Issue 9, Pages 880-881 (May 2009) DOI: 10.1038/ki.2008.692 Copyright © 2009 International Society of Nephrology Terms and Conditions

Figure 1 Phosphorus-induced alterations in calcium and/or vitamin D metabolism change parathyroid gland function in chronic kidney disease. 1, CASR: cell suface G protein–coupled receptor of extracellular ionized Ca2+; 2, vitamin D receptor: nuclear receptor controlling gene transcription; 3, putative phosphate sensor; 4, FGF23 is a negative regulator of parathyroid function. Adapted from Quarles.3 Kidney International 2009 75, 880-881DOI: (10.1038/ki.2008.692) Copyright © 2009 International Society of Nephrology Terms and Conditions