DNA Makes RNA Makes Innate Immunity

Slides:



Advertisements
Similar presentations
Pattern recognition receptors (PRRs)
Advertisements

Alexander Loewer, Galit Lahav  Cell 
Identification and functions of pattern-recognition receptors
Luke A.J. O'Neill, Andrew G. Bowie  Cell 
Cutting Edge in IFN Regulation: Inflammatory Caspases Cleave cGAS
Cytosolic DNA Sensing: The Field Narrows
Inna S. Afonina, Christina Müller, Seamus J. Martin, Rudi Beyaert 
A Nurr1 Pathway for Neuroprotection
Cytokines, Skin, and Smallpox–A New Link to an Antimicrobial Peptide
Identification and functions of pattern-recognition receptors
Innate DNA Sensing Moves to the Nucleus
Nader Yatim, Matthew L. Albert  Immunity 
The Birds, the Bees, and Innate Immunity
Figure 1 Activation and signalling of IL-1
IL-33 Raises Alarm Immunity Volume 31, Issue 1, Pages 5-7 (July 2009)
Did Cholera Toxin Finally Get Caught?
Mechanism and Regulation of NLRP3 Inflammasome Activation
Fishing Out a Sensor for Anti-inflammatory Oils
Innate immunity as a driving force in renal disease
Andrew Blauvelt, Mark G. Lebwohl, Robert Bissonnette 
Endosomes as Platforms for NOD-like Receptor Signaling
Dieter Demon, Lieselotte Vande Walle, Mohamed Lamkanfi 
Cyclic Dinucleotides and the Innate Immune Response
In This Issue Cell Volume 158, Issue 5, (August 2014)
DNA Polymerases at the Replication Fork in Eukaryotes
Pathogen Recognition and Innate Immunity
Volume 49, Issue 1, Pages 4-8 (January 2006)
Volume 3, Issue 6, Pages (June 2008)
Interferon-α and -β in kidney inflammation
Effects of air pollutants on innate immunity: The role of Toll-like receptors and nucleotide-binding oligomerization domain–like receptors  Rebecca N.
Key airway signaling pathways induced by respiratory viruses.
Connecting Mitochondria and Innate Immunity
Volume 146, Issue 7, Pages (June 2014)
RIG-I Holds the CARDs in a Game of Self versus Nonself
John G. Monroe, Mary E. Keir  Immunity 
Anti-inflammatory Agents: Present and Future
Inflammasome Activation: How Macrophages Watch What They Eat
The cGAS-STING Defense Pathway and Its Counteraction by Viruses
Superficial Immunity: Antimicrobial Responses Are More Than Skin Deep
How Low Cholesterol Is Good for Anti-viral Immunity
Roles of Caspases in Necrotic Cell Death
Taro Kawai, Shizuo Akira  Immunity  Volume 34, Issue 5, Pages (May 2011)
Fishing Out a Sensor for Anti-inflammatory Oils
Cytosolic Sensing of Viruses
Proteins in Plant Brassinosteroid Signaling
Toll-like receptors Current Biology
Therapeutic strategies in inflammasome mediated diseases of the liver
Tobias R. Kollmann, Ofer Levy, Ruth R. Montgomery, Stanislas Goriely 
Inflammasome Complexes: Emerging Mechanisms and Effector Functions
Signaling Organelles of the Innate Immune System
Linking Retroelements to Autoimmunity
Innate Recognition of Viruses
Immune Signaling by RIG-I-like Receptors
Innate Immunity: Cytoplasmic DNA Sensing by the AIM2 Inflammasome
Mechanisms and Functions of Inflammasomes
Mesenchymal Stromal Cells: Sensors and Switchers of Inflammation
Immunity unmasks APOL1 in collapsing glomerulopathy
Teeing Up Transcription on CpG Islands
Intracellular NOD-like Receptors in Host Defense and Disease
Mesenchymal Stromal Cells: New Directions
Innate Immune Recognition of mtDNA—An Undercover Signal?
Figure 5 TLR-dependent signaling pathways inhibited by glatiramer acetate Myeloid differentiation primary response gene 88 (MyD88) and Toll-IL-1 receptor.
Viperin Poisons Viral Replication
CD14: Chaperone or Matchmaker?
Signal transduction pathways and activation of the innate immune response. Signal transduction pathways and activation of the innate immune response. In.
TAMpering with Toll-like Receptor Signaling
cGAS Dimerization Entangles DNA Recognition
Signaling to NF-κB by Toll-like receptors
Sensing of HMPV by different PRRs and modulation of the IFN response by viral proteins. Sensing of HMPV by different PRRs and modulation of the IFN response.
Toll-like receptors, adapter proteins, and signaling molecules.
Presentation transcript:

DNA Makes RNA Makes Innate Immunity Luke A.J. O'Neill  Cell  Volume 138, Issue 3, Pages 428-430 (August 2009) DOI: 10.1016/j.cell.2009.07.021 Copyright © 2009 Elsevier Inc. Terms and Conditions

Figure 1 DNA Sensing and Innate Immunity Shown are signaling pathways that detect microbial DNA in the host cell cytosol resulting in an innate immune response. In a newly discovered pathway (Chiu et al., 2009), a cytosolic DNA-dependent RNA polymerase III (Pol III) detects AT-rich double-stranded DNA (dsDNA) released by pathogens. Pol III converts this pathogen dsDNA into dsRNA that has a 5′ triphosphate. This RNA species is then sensed by the RNA sensor RIG-I, leading to IFN-β production and activation of innate immunity. Other well-established pathways sense microbial DNA in different cellular compartments, triggering production of different sets of cytokines. For example, Toll-like receptor 9 (TLR9) in endosomes senses CpG motifs in microbial DNA and activates signaling pathways, culminating in activation of NF-κB and IRF7 with subsequent production of proinflammatory cytokines and type I IFNs. Cytosolic DNA derived from vaccinia virus can be sensed by AIM2 in a complex with Asc and caspase-1, leading to the processing of pro-IL-1β to IL-1β. In certain cultured cell lines, AT-rich dsDNA can also be sensed by the protein DAI, which drives IFN-β production through activation of the protein kinase TBK-1. Finally, an as yet unknown receptor detects several types of microbial DNA, including plasmid-derived and GC-rich DNA in some cell types, leading to IFN-β production via activation of TBK-1. Cell 2009 138, 428-430DOI: (10.1016/j.cell.2009.07.021) Copyright © 2009 Elsevier Inc. Terms and Conditions