Mechanisms of tubulointerstitial injury in IgA nephropathy

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Mechanisms of tubulointerstitial injury in IgA nephropathy Kar Neng Lai, Loretta Y.Y. Chan, Joseph C.K. Leung Kidney International Volume 67, Pages S110-S115 (April 2005) DOI: 10.1111/j.1523-1755.2005.09426.x Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 1 Representative immunohistologic staining in kidney biopsy from patients with IgAN. (A) Immunofluoresence study revealing mesangial IgA deposition with IgA cast in tubular lumen (solid arrow) and absence of tubular IgA deposits (open arrow) (magnification ×400). (B) Immunoperoxidase study (visualized by the Dako Envision plus system) revealing mesangial IgA deposition and absence of tubular IgA deposits (magnification ×400). (C) Immunoperoxidase study (visualized by the Dako Envision plus system) revealing mesangial and tubular deposition of TGF-β (magnification ×250). (D) Immunoperoxidase study revealing no IgA deposition in control kidney tissue (magnification ×400). Kidney International 2005 67, S110-S115DOI: (10.1111/j.1523-1755.2005.09426.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 2 Representative immunofluorescent staining of IgA binding to human mesangial cells (MC) and human proximal tubular epithelial cells (PTEC). Binding of IgA from IgAN patients to HMC (C) was higher than that from healthy controls (CTL) (B). Binding of IgA from IgAN patients (F) or healthy controls (E) to PTEC was barely detectable. No positive staining was observed in HMC (A) or PTEC (D) stained with isotype control antibody (magnification ×400). Kidney International 2005 67, S110-S115DOI: (10.1111/j.1523-1755.2005.09426.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 3 Schematic model of the variable mechanisms operating between the HMC, podocytes, and PTEC following mesangial IgA deposition in the development of tubulointerstitial injury in progressive IgAN. Kidney International 2005 67, S110-S115DOI: (10.1111/j.1523-1755.2005.09426.x) Copyright © 2005 International Society of Nephrology Terms and Conditions