What is the major conclusion of this paper?

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Presentation transcript:

What is the major conclusion of this paper? presenilin 1 is likely the ϒ-secretase Presenilin 1 can cleave Notch Presenilin 1 can cleave APP Presenilin 1 is important for intramembranous cleavage of Notch None of the above

Pulse-chase experiments are used To monitor the fate, stability, or movement of a molecule over a period of time To monitor the cleavage of a protein by a protease To label a protein with radioactive isotopes To detect proteins expressed at very low levels None of the above.

The authors used protease inhibitors to provide definitive evidence that ϒ-secretase is involved in Notch processing correlative evidence that ϒ-secretase is involved in Notch processing evidence that a protease is involved in processing of both APP and Notch evidence that the proteasome is involved in degradation of APP and Notch None of the above

This study shows that Notch and APP are proteins with similar functions likely processed by ϒ-secretase both important trans-membrane proteins likely processed by α-secretase related in functions