Immunomodulation with interleukin-10 and interleukin-4 compared with ketorolac tromethamine for prevention of postoperative adhesions in a murine model 

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Immunomodulation with interleukin-10 and interleukin-4 compared with ketorolac tromethamine for prevention of postoperative adhesions in a murine model  Christine H Holschneider, M.D., Farshid Nejad, B.S., F.J Montz, M.D.  Fertility and Sterility  Volume 71, Issue 1, Pages 67-73 (January 1999) DOI: 10.1016/S0015-0282(98)00393-8

FIGURE 1 (A) Effects of different doses of IL-10 on postoperative adhesion formation reported as geometric means of adhesion scores with 95% confidence intervals (CIs). Group 1: no injections; group 2: PBS only; group 3: 10 ng/kg; group 4: 100 ng/kg; group 5: 1 μg/kg; group 6: 10 μg/kg; and group 7: 100 μg/kg. (Reprinted from Holschneider et al. [13]). (B) Effects of different doses of IL-4 on postoperative adhesion formation reported as geometric means of adhesion scores with 95% CIs. Group 1: no injections; group 2: PBS only; group 3: 10 ng/kg; group 4: 100 ng/kg; group 5: 1 μg/kg; and group 6: 10 μg/kg. Fertility and Sterility 1999 71, 67-73DOI: (10.1016/S0015-0282(98)00393-8)

FIGURE 2 Postoperative adhesion scores reported as geometric means with 95% confidence intervals (CIs) for nonsurgical control animals (groups 1–9) and animals who underwent surgery (groups 10–18). For 3 days, animals received either no injections (groups 1 and 10), PBS only (groups 2 and 11), IL-10 (groups 3 and 12), IL-4 (groups 4 and 13), ketorolac (groups 5 and 14), IL-10 plus IL-4 (groups 6 and 15), IL-10 plus ketorolac (groups 7 and 16), IL-4 plus ketorolac (groups 8 and 17), or IL-10 plus IL-4 plus ketorolac (groups 9 and 18). Fertility and Sterility 1999 71, 67-73DOI: (10.1016/S0015-0282(98)00393-8)