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Volume 12, Issue 22, Pages 1959-1964 (November 2002) Gene Clustering Based on RNAi Phenotypes of Ovary-Enriched Genes in C. elegans Fabio Piano, Aaron J. Schetter, Diane G. Morton, Kristin C. Gunsalus, Valerie Reinke, Stuart K. Kim, Kenneth J. Kemphues Current Biology Volume 12, Issue 22, Pages 1959-1964 (November 2002) DOI: 10.1016/S0960-9822(02)01301-5

Figure 1 Correlation between RNAi Phenotypic Classes and Expression Levels in the Ovary for the Set of 751 Genes Tested Expression level is expressed as fold-enrichment detected in wild-type versus glp-4 mutant adults, in which the germline is absent. The number of genes in each fold-induction range falling into different RNAi phenotypic classes is expressed as a percentage of the total number (n) of genes in each bin. Dark gray bars represent genes giving rise to maternal sterility or strong (≥80%) embryonic lethality. Light gray bars represent genes giving rise to partial (10%–80%) embryonic lethality. Black bars represent genes giving rise to postembryonic phenotypes only. White bars represent genes giving rise to no detectable phenotype. Current Biology 2002 12, 1959-1964DOI: (10.1016/S0960-9822(02)01301-5)

Figure 2 Expected versus Observed Distribution by Chromosomes of Genes Giving Rise to Maternal Sterility and/or Some Level of Embryonic Lethality in the Set of 751 Ovary-Enriched Genes Tested by RNAi Light gray bars represent the expected number of genes on each chromosome based on the total number of predicted protein-encoding genes in the genome (20,379 ORFs from WormPep73). Dark gray bars represent the expected number of genes based on the chromosomal distribution of genes in the set of 751 genes tested. Black bars represent the observed number of genes. Current Biology 2002 12, 1959-1964DOI: (10.1016/S0960-9822(02)01301-5)

Figure 3 Gene Cluster Display Based on RNAi-Induced Phenotypes in the Early Embryo (A) A cladogram of 161 GenePairs derived with 47 phenotypic descriptors. Each node represents one GenePair tested; where available, the corresponding gene name is also indicated. Some groups are discussed in the text and are represented by roman numerals and by shaded boxes. The pie charts show the distribution of predicted sequence-based function for the genes in each group. (B) Pie chart representing all the genes in (A). The following categories are represented in all the pie charts: 1, unknown; 2, RNA transcription/modification; 3, chromatin/chromosome structure; 4, cell cycle control; 5, protein synthesis/folding/translocation/degradation; 6, energy metabolism; 7, Signal transduction/differentiation; 8, cytoskeleton associated or component; 9, Nuclear-cytoplasmic transport; and 10, chitin biosynthesis. Current Biology 2002 12, 1959-1964DOI: (10.1016/S0960-9822(02)01301-5)