Role of regulatory T cells and FOXP3 in human diseases

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Presentation transcript:

Role of regulatory T cells and FOXP3 in human diseases Rosa Bacchetta, MD, Eleonora Gambineri, MD, Maria-Grazia Roncarolo, MD Journal of Allergy and Clinical Immunology Volume 120, Issue 2, Pages 227-235 (August 2007) DOI: 10.1016/j.jaci.2007.06.023 Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Cytokine and transcription factor interactions in the development of effector and regulatory immune responses. Depending on the type of antigen, site, and cells involved in antigen presentation, different soluble factors and membrane molecules trigger different genes driving the cell fate and functions of different subsets of both effector T helper cells (TH) and Treg cells. Ag, Antigen; AutoAg, autoantigen; ROG, repressor of GATA. Journal of Allergy and Clinical Immunology 2007 120, 227-235DOI: (10.1016/j.jaci.2007.06.023) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Currently available procedures to generate Treg cells for cellular therapy. Depending on the type of Treg cells, different approaches can be designed for their expansion/induction, and multiple therapeutic indications can be envisaged. Ag, Antigen; SLE, systemic lupus erythematosus; Tx, treatment; GvHD, graft versus host disease. Journal of Allergy and Clinical Immunology 2007 120, 227-235DOI: (10.1016/j.jaci.2007.06.023) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions