Fig. 4. Clearance of 12-mer-1 from a nonhuman primate model.

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Fig. 4. Clearance of 12-mer-1 from a nonhuman primate model. Clearance of 12-mer-1 from a nonhuman primate model. M. mulatta monkeys were treated with 12-mer-1 at a dose of 250 μg/kg either intravenously (IV) (A) or subcutaneously (SC) (B). Blood samples were collected before dosing (at t = 0 hour) and at 30, 60, and 120 min after dosing (for IV group) or at 1, 2, 4, and 6 hours after dosing (for SC group). The plasma concentration of 12-mer-1 was determined by measuring the activity of FXa, which was converted into the concentration of 12-mer-1 by a standard curve, as shown in fig. S21. Data are average ± range (n = 2). Yongmei Xu et al., Sci Transl Med 2017;9:eaan5954 Published by AAAS