D. Kumar, D. C. Karampinos, T. D. MacLeod, W. Lin, L. Nardo, X. Li, T

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Quadriceps intramuscular fat fraction rather than muscle size is associated with knee osteoarthritis D. Kumar, D.C. Karampinos, T.D. MacLeod, W. Lin, L. Nardo, X. Li, T.M. Link, S. Majumdar, R.B. Souza Osteoarthritis and Cartilage Volume 22, Issue 2, Pages 226-234 (February 2014) DOI: 10.1016/j.joca.2013.12.005 Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Comparison of fat distribution and fat content at a representative slice between a control subject (first row) and an ROA subject (second row) with the same age, gender and similar total muscle lean ACSA. The first column shows the fat fraction maps (color bar units in %). The second column shows color-coded fat fraction maps highlighting the intraMF fraction (red), intermuscular fat fraction (green) and SAT (blue) regions. The third columns shows color-coded fat fraction maps highlighting the quadriceps (red), hamstrings (green) and other muscle (blue) regions. The color-coded maps were weighted by the fat fraction map values. Osteoarthritis and Cartilage 2014 22, 226-234DOI: (10.1016/j.joca.2013.12.005) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Fat fractions for control subjects (Black) and OA (Gray) with 95% CI for quadriceps muscle, hamstrings muscle, all remaining muscles and global compartments. (b) Lean ACSA control subjects (Black) and OA (Gray) with 95% CI for quadriceps muscle, hamstrings muscle, all remaining muscles and global compartments. Brackets indicate significant differences at P < 0.05. Osteoarthritis and Cartilage 2014 22, 226-234DOI: (10.1016/j.joca.2013.12.005) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Scatter-plots for the association of quadriceps intraMF fraction (y-axes) with (a) age, (b) KL, (c) total cartilage mWORMS score, and (d) total meniscus mWORMS score on the x-axes. Osteoarthritis and Cartilage 2014 22, 226-234DOI: (10.1016/j.joca.2013.12.005) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions