Volume 135, Issue 1, Pages 122-130 (July 2008) Increased Liver Fat, Impaired Insulin Clearance, and Hepatic and Adipose Tissue Insulin Resistance in Type 2 Diabetes  Anna Kotronen, Leena Juurinen, Mirja Tiikkainen, Satu Vehkavaara, Hannele Yki–Järvinen  Gastroenterology  Volume 135, Issue 1, Pages 122-130 (July 2008) DOI: 10.1053/j.gastro.2008.03.021 Copyright © 2008 AGA Institute Terms and Conditions

Figure 1 Relationship between liver fat content and insulin clearance in the nondiabetic subjects (open circles) and the type 2 diabetic patients (closed circles). r = −0.41. P = .001. Gastroenterology 2008 135, 122-130DOI: (10.1053/j.gastro.2008.03.021) Copyright © 2008 AGA Institute Terms and Conditions

Figure 2 The relationship between liver fat content and hepatic insulin resistance. r = 0.46. P = .0001. Symbols as in Figure 1. Gastroenterology 2008 135, 122-130DOI: (10.1053/j.gastro.2008.03.021) Copyright © 2008 AGA Institute Terms and Conditions

Figure 3 Relationship between liver fat content and (A) percent suppression of S-FFA concentrations by insulin (the gray line represents the nondiabetic subjects [r = 0.47; P = .005], and the black line represents the type 2 diabetic patients [r = 0.39; P = .025]. The difference between the intercepts is statistically significant [P = .003]). (B) Adipose tissue insulin sensitivity (r = 0.55; P < .0001). Symbols as in Figure 1. Gastroenterology 2008 135, 122-130DOI: (10.1053/j.gastro.2008.03.021) Copyright © 2008 AGA Institute Terms and Conditions