A single nucleotide polymorphism in the p27Kip1 gene is associated with primary patency of lower extremity vein bypass grafts Michael S. Conte, MD, Christopher.

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Presentation transcript:

A single nucleotide polymorphism in the p27Kip1 gene is associated with primary patency of lower extremity vein bypass grafts Michael S. Conte, MD, Christopher D. Owens, MD, Michael Belkin, MD, Mark A. Creager, MD, Karen L. Edwards, PhD, Warren J. Gasper, MD, Richard D. Kenagy, PhD, Renee C. LeBoeuf, PhD, Michael Sobel, MD, Alexander Clowes, MD Journal of Vascular Surgery Volume 57, Issue 5, Pages 1179-1185.e2 (May 2013) DOI: 10.1016/j.jvs.2012.11.040 Copyright © 2013 Society for Vascular Surgery Terms and Conditions

Fig 1 Life-table plot shows primary lower extremity vein bypass graft patency by p27 kip1-838 genotype for the 204 individuals in the Boston cohort. Data are shown with the standard error of the mean brackets. Journal of Vascular Surgery 2013 57, 1179-1185.e2DOI: (10.1016/j.jvs.2012.11.040) Copyright © 2013 Society for Vascular Surgery Terms and Conditions

Fig 2 Life-table plot shows primary lower extremity vein bypass graft patency by p27Kip-838 genotype, using a recessive model (AA vs CA + CC). Data are shown with the standard error of the mean. Journal of Vascular Surgery 2013 57, 1179-1185.e2DOI: (10.1016/j.jvs.2012.11.040) Copyright © 2013 Society for Vascular Surgery Terms and Conditions

Fig 3 Percentage change (mean ± standard deviation) is shown in vein graft lumen diameter from baseline (intraoperative after implantation) to 1 month, in a subset of 55 patients who took part in a detailed ultrasound imaging substudy,18 by p27Kip1-838 genotype (P = .045 by analysis of variance). Journal of Vascular Surgery 2013 57, 1179-1185.e2DOI: (10.1016/j.jvs.2012.11.040) Copyright © 2013 Society for Vascular Surgery Terms and Conditions

Supplementary Fig (online only) Effect of the p27 kip1-838C>A polymorphism on p27Kip1 promoter activity in human venous fibroblasts. Primary cultured adventitial fibroblasts from human saphenous vein (Kenagy et al J Vasc Surgery 2009; 49:1282-8) were transfected by electroporation with the indicated p27Kip1 promoter-luciferase constructs used by van Tiel et al (Circulation 2009; 120:669-676) containing the -838A or -838C variant. One day after transfection, cells were changed to serum-free medium for 24 hours and firefly luciferase activity measured. Luciferase activity was normalized to Renilla luciferase and expressed as fold of the empty pGL3 shuttle vector. Data shown are mean of four independent experiments (P < .006 by paired t-test). Journal of Vascular Surgery 2013 57, 1179-1185.e2DOI: (10.1016/j.jvs.2012.11.040) Copyright © 2013 Society for Vascular Surgery Terms and Conditions