FGF21 and the Second Coming of PPARγ Li Qiang, Domenico Accili  Cell  Volume 148, Issue 3, Pages 397-398 (February 2012) DOI: 10.1016/j.cell.2012.01.020 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 Representative Diagram of the Proposed Mechanism of FGF21 Action Liver is the primary source of circulating FGF21, and hepatic synthesis is driven by PPARα activation. In addition, adipocytes are a secondary source of FGF21. But unlike hepatocytes, adipocytes make FGF21 in response to PPARγ agonists (TZDs) or feeding. Plasma levels of FGF21 don't change significantly following PPARγ activation, indicating that adipocyte-derived FGF21 acts locally. Its main role appears to be to potentiate the effects of PPARγ activation on adipocyte differentiation and gene expression. Nonetheless, systemic actions of PPARγ agonists are also impaired by the loss of FGF21. Cell 2012 148, 397-398DOI: (10.1016/j.cell.2012.01.020) Copyright © 2012 Elsevier Inc. Terms and Conditions