Parathyroid growth and regression in experimental uremia

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Parathyroid growth and regression in experimental uremia M. Taniguchi, M. Tokumoto, D. Matsuo, K. Tsuruya, H. Hirakata, M. Iida Kidney International Volume 69, Issue 3, Pages 464-470 (February 2006) DOI: 10.1038/sj.ki.5000090 Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 1 Typical immunohistochemical findings of VDR, CaSR, and p21 protein expression in PT tissues resected from (a–c) NR and (d–f) UR-4w. VDR in UR-1d, CaSR in UR-5d, and p21 in UR-1d are shown in (g–i), respectively (original magnification × 400). (a, d, g) VDR and (c, f, i) p21 proteins showed mainly nuclear localization. (b, e, h) CaSR protein showed cell-membranous or cytosolic localization. The expression levels of these proteins decreased in a time-dependent manner after the onset of renal failure. Kidney International 2006 69, 464-470DOI: (10.1038/sj.ki.5000090) Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 2 Representative immunohistochemical findings of Ki67 antigen in PT tissues resected from (a) NR (b) UR-3d (original magnification × 400). Ki67-positive cells obviously increased 3 days after 5/6 nephrectomy. Kidney International 2006 69, 464-470DOI: (10.1038/sj.ki.5000090) Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 3 Representative immunohistochemical findings of VDR, CaSR, and p21 protein expression in PT tissues resected from (a, d, g) Sx-12w, (b, e, h) UR-12w, and (c, f, i) UVD-12w (original magnification × 400). (j–l) Cell death was identified by TUNEL assay and microscopic findings of PT tissues (m–o; hematoxylin staining) in each group (original magnification × 400). The expression levels of VDR, CaSR and p21 proteins were upregulated after VD3 treatment. Note the marked increase in TUNEL-positive cells in (l) UVD-12w compared with (k) UR-12w. The CS in UVD-12w (Figure 1o) diminished compared with UR-12w (Figure 1n). Kidney International 2006 69, 464-470DOI: (10.1038/sj.ki.5000090) Copyright © 2006 International Society of Nephrology Terms and Conditions