NAMIC AHM, Jan 7-11, 2008 – Salt Lake City, Utah

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Presentation transcript:

NAMIC AHM, Jan 7-11, 2008 – Salt Lake City, Utah Stochastic Tractography Group Study of Arcuate Fasciculus in Schizophrenia Doug Markant,Tri Ngo, Marek Kubicki PNL, BWH NAMIC AHM, Jan 7-11, 2008 – Salt Lake City, Utah

Methods 12 Controls, 7 Schizophrenia DWI Data: White matter mask Final Study will have 18 Controls, 18 Schizophrenia DWI Data: 3 T Eddy Current Corrected Rician Noise Filtered White matter mask Freesurfer Segmentation ROI Generation Superior Temporal Gyrus, Inferior Frontal Gyrus Manual “Waypoint” ROI for tract selection

Methods Computational Resources: Dual Core AMD Opteron(tm) Processor 880 x 8 63.05 GB ram Average algorithm execution time per case: 40 mins

Methods: Inputs Stochastic Tractography Filter ROITract Filter Max Length: 2000 mm Step Size: 1 mm Tract Samples/ROI voxel: 5000 Maximum bending: 90 degrees per segment Stopping criteria: Max length, Leaving white matter mask ROITract Filter Tracts must pass encounter all 3 ROIs Exclude tract inside ROI’s.

Previous Results

Results Waypoint ROI

Results: Mean Subject FA, Connectivity>0.1 Blue: Control Red: Schiz.

Results: Mean Weighted FA Blue: Control Red: Schiz.

Results: Mean Trace, Connectivity>0.1 Blue: Control Red: Schiz.

Results: Mean Weighted Trace Blue: Control Red: Schiz.

Conclusions Significant Increase in right mean trace in Schizophrenia Group. Future Work: Localized Tract Comparison using groupwise registration

Results: Overview FA Trace Mode Subjects