Synthesis of Collagen I in Collagenous Sprue Severin Daum, Hans–Dieter Foss, Detlef Schuppan, Ernst–Otto Riecken, Martin Zeitz, Reiner Ullrich  Clinical Gastroenterology and Hepatology  Volume 4, Issue 10, Pages 1232-1236 (October 2006) DOI: 10.1016/j.cgh.2006.07.003 Copyright © 2006 American Gastroenterological Association (AGA) Institute Terms and Conditions

Figure 1 Immunohistochemistry of duodenal biopsies of a patient with uncomplicated, untreated CD (A) and patient 1 with CS (B) stained with antibodies against tenascin showing a broad positive subepithelial band in the patient with CS (arrows). Original magnification 100×. Localization of procollagen I mRNA in the duodenal mucosa in uncomplicated CD (C) and in CS (patient 1) (D) by in situ hybridization. Black grains indicate hybridization of RNA-antisense probes to mRNA in the tissue. Expression of collagen I mRNA is increased in CS in the subepithelial cell layer (arrows). Procollagen I mRNA positive cells were morphologically assessed as fibroblasts and myofibroblasts. Original magnification 200×. Clinical Gastroenterology and Hepatology 2006 4, 1232-1236DOI: (10.1016/j.cgh.2006.07.003) Copyright © 2006 American Gastroenterological Association (AGA) Institute Terms and Conditions