Dancing transcription factors: What makes SOX9 move?

Slides:



Advertisements
Similar presentations
Full-thickness cartilage defects repaired by human induced pluripotent stem cells (IPSCS)-derived mesenchymal stem cells and plga scaffolds D. Shi, X.
Advertisements

Comparative efficacy of oral non-steroidal anti-inflammatory drugs and opioids for osteoarthritis: Systematic review and meta-analysis  S.R. Smith, B.R.
Full-thickness cartilage defects repaired by human induced pluripotent stem cells (IPSCS)-derived mesenchymal stem cells and plga scaffolds  D. Shi, X.
G.-I. Im, H.-J. Kim  Osteoarthritis and Cartilage 
R. Takeuchi, H. Ishikawa, T. Kuniya, A. Nakazawa 
K.S. Santangelo  Osteoarthritis and Cartilage 
S. Gavard  Osteoarthritis and Cartilage 
Injectable hydrogels for cartilage repair
Prospective economic evaluation of the costs for medications and nutraceuticals in knee osteoarthritis  M. Chung, N. Zhao, J.B. Wong, C. Wang  Osteoarthritis.
Characterization of cartilage repair in a focal mouse defect model
Biochemical markers of synovial inflammation – Surrogate markers of synovitis on magnetic resonance imaging? – Data from the osteoarthritis initiative 
Osteoarthritis year 2011 in review: biochemical markers of osteoarthritis: an overview of research and initiatives  Y. Henrotin  Osteoarthritis and Cartilage 
Decreased proteoglycan degradation in IL-1β-treated cartilage co-cultured with TIMP-3- transduced cells  J. Mason, A. Donahue, A. Yoskowitz, D. Richardson 
Human synovial fluid derived mesenchymal stem cells expanded under low oxygen conditions and in a serum-free environment exhibit enhanced lineage-specific.
Role of endothelin-1 in endochondral ossification and osteoarthritis
Effect of self assembled peptide-mesenchymal stem cell complex on delaying the progression of osteoarthritis  S. Kim, S. Lee, Y. Jung, J. Kim, S. Kim 
G. Venne, S. Pang, Y. Tse, R. Ellis  Osteoarthritis and Cartilage 
Z. Zhang, W. Liao, Z. Zhang, X. Duan, C. Hou 
Replicability of recommended exercise interventions for knee osteoarthritis: a descriptive systematic review of current clinical guidelines and recommendations 
Identification of p21 inhibitors to enhance chondrogenesis in osteoarthritic synovial mesenchymal progenitor cells  K.L. Bertram, T. Irvine, P. Tailor,
Recovery of Free-living Daily Walking within the First Month after Total Knee Arthroplasty: A Preliminary Study  M.B. Christiansen, L. Thoma, H. Master,
Association of ultrasound-defined structural changes with regional and diffuse knee pain patterns – Oulu Knee Osteoarthritis study  J. Podlipská, P. Kaukinen,
Y. Zhou, L. Resutek, L. Wang, X. Lu  Osteoarthritis and Cartilage 
Osteoarthritis and Cartilage
Characterising movement patterns in elite male professional golfers using an observational hip and lower limb movement screen  N. Booysen, D. Wilson,
Stem cell therapy for human cartilage defects: a systematic review
Role of TCF4 in signaling crosstalk with NFκB in human chondrocytes
Different responses of healthy, relative healthy and OA chondrocytes with IL1β treatment under hypoxia and normoxia  X. Huang, L. Zhong, J. Post, M. Karperien 
Y. Levy, A. Hasegawa, S. Patil, M. Lotz, D. D'Lima 
K.S. Vanderman, R. Loeser, S. Chubinskaya, C.M. Ferguson 
The Differences of the Viscoelastic Behavior among Intra-articular Injections of Hyaluronan Formulation  H. Hoshi, K. Miyamoto  Osteoarthritis and Cartilage 
Osteoarthritis and Cartilage
Responsiveness of infra-patellar fat pad (IPFP) volume change with severe body weight gain and loss – Data from the OAI  E. Steidle-Kloc, T. Dannhauer,
K. Hashimoto, K. El-Hachem, M. Otero, M.B. Goldring 
Regionally distinct f-actin networks within articular cartilage
Osteoarthritis and Cartilage
G. Plumton, I. Adjei, A. Martin-Pena, G.D. Palmer, B. Sharma 
Who should have a joint replacement? A plea for more ‘phronesis’
Structural Damage of the Thumb Base in Patients With Hand Osteoarthritis, Assessment by Magnetic Resonance Imaging Compared to Standard Radiography  S.
Emerging role of endothelin receptor type B in regulating chondrogenic and hypertrophic changes of human mesenchymal stem cells  M. Au, M. Zhu, W.-J.
N. Khalaj, N.A. Osman, W. Wan Abas, A. Mokhtar 
M. Baharuddin, S.-H. Salleh, M. Lee, A. Mohd Noor 
Z. Huang, T. Stabler, F. Pei, V. Kraus  Osteoarthritis and Cartilage 
An ECHO in biology II: Insights in chondrocyte cell fate
Oxygen regulates lipid profiles in human primary chondrocyte cultures
The risk of osteoarthritis progression after arthroscopic partial meniscectomy (APM); data from an rct of APM vs. physical therapy  J.E. Collins, E. Losina,
Comparative efficacy of oral non-steroidal anti-inflammatory drugs and opioids for osteoarthritis: Systematic review and meta-analysis  S.R. Smith, B.R.
Evidence for bone mineral density and bone resorption in middle and elderly women with knee osteoarthritis in Shanghai: a cross sectional study  Q. Xiaofeng 
Osteoarthritis and Cartilage
Walking with increased foot progression angle can reduce joint compression in individuals with knee OA  K. Manal, T.S. Buchanan  Osteoarthritis and Cartilage 
Battling low back pain with novel NP cell models
Multivariate pattern analysis of physical activity and cartilage health: data from the osteoarthritis initiative  E. Halilaj, T.J. Hastie, G.E. Gold,
SOX9 transcriptional activity is dependent on the chondrocyte health state and is directly regulated by WNT3A, IL1β and BMP7  K. Govindaraj, M. Karperien,
Osteoarthritis and Cartilage
Imaging biomarker with T1 and T2 mappings in osteoarthritis – In vivo human articular cartilage study  C. Yan, C. Wong, T. Li, N. Gong, Q. Chan, K. Chiu 
Osteoarthritis year 2012 in review: biology
How does lower leg alignment differ between soccer players, other athletes and non- athletic controls?  W. colyn, R. Agricola, N. Arnout, J. Verhaar, J.
Hip derived synovial mesenchymal progenitor cell surface markers as indicators for differentiation potential  A. Affan, N. Al-Jezani, P. Railton, J. Powell,
The elastic modulus of articular cartilage at nano-scale and micro-scale measured using indentation type atomic force microscopy  P. Rahnamay Moshtagh,
H. Khan, D. Aitken, C. Ding, L. Blizzard, J. -P. Pelletier, J
J.H. Ylärinne, C. Qu, M.J. Lammi  Osteoarthritis and Cartilage 
Knee kinematic and kinetic modifications under body weight unloading during overground walking at a constant speed  A.G. Fischer, E.M. Debbi, A. Wolf 
Adhesive barrier/directional controlled release for cartilage repair by endogenous progenitor cell recruitment  G.-I. Im, J.-M. Lee, E.-A. Kim  Osteoarthritis.
Amyloid micronetworks for cartilage repair
Synovial fluid concentration of gremlin1 but not frizzled-related protein is increased in patients after acute knee injury  L. Zhong, J. Leijten, J. Post,
Fully automated segmentation of cartilage from magnetic resonance images using improved 3D shape context and active shape model  T. Ye, X. Cui, H. Kim 
In This Issue Cell Volume 145, Issue 3, (April 2011)
A. Carlson, B. Bothner, R. June  Osteoarthritis and Cartilage 
General Information Osteoarthritis and Cartilage
Long-term effects of vitamin d supplementation and maintaining vitamin d sufficiency on knee osteoarthritis over 5 years  B. Antony, S. Zheng, J. Burgess,
Presentation transcript:

Dancing transcription factors: What makes SOX9 move? K. Govindaraj, M. Karperien, J.N. Post  Osteoarthritis and Cartilage  Volume 24, (April 2016) DOI: 10.1016/j.joca.2016.01.339 Copyright © 2016 Terms and Conditions

Figure 1 Time lapse imaging of fluorescence recovery after photobleaching of C20/A4 cells transfected with mGFP (control) or SOX9-mGFP with and without WNT3A. Scale bar 5μm. Osteoarthritis and Cartilage 2016 24, DOI: (10.1016/j.joca.2016.01.339) Copyright © 2016 Terms and Conditions

Figure 2 FRAP curve showing change of SOX9-mGFP mobility in response to WNT3A. Osteoarthritis and Cartilage 2016 24, DOI: (10.1016/j.joca.2016.01.339) Copyright © 2016 Terms and Conditions