Mahesh Mysore Shivananjappa, Muralidhara

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Presentation transcript:

Taurine attenuates maternal and embryonic oxidative stress in a streptozotocin-diabetic rat model Mahesh Mysore Shivananjappa, Muralidhara Reproductive BioMedicine Online Volume 24, Issue 5, Pages 558-566 (May 2012) DOI: 10.1016/j.rbmo.2012.01.016 Copyright © 2012 Reproductive Healthcare Ltd. Terms and Conditions

Figure 1 Effect of oral taurine supplementation on gestation days 5–12 on concentrations of reactive oxygen species (ROS) (A) and malondialdehyde (MDA) (B) in embryos of pregnant rats rendered diabetic by an acute dose of streptozotocin on gestation day 4. Values are mean±SD (15 embryos per group; two embryos each from five dams). aP<0.05 (compared with control); bP<0.05 (compared with STZ). STZ=streptozotocin 45mg/kg bodyweight; TAU1=taurine supplementation 0.5g/kg bodyweight; TAU2=taurine supplementation 1g/kg bodyweight. Reproductive BioMedicine Online 2012 24, 558-566DOI: (10.1016/j.rbmo.2012.01.016) Copyright © 2012 Reproductive Healthcare Ltd. Terms and Conditions

Figure 2 Effect of oral taurine supplementation on gestation days 5–12 on concentrations of protein carbonyls (A) and antioxidants (B) in embryos of pregnant rats rendered diabetic by an acute dose of streptozotocin on gestation day 4. Values are mean±SD (18 embryos per group; two embryos each from six dams). Data were analysed by two-way ANOVA. aP<0.05 (compared with control); bP<0.05 (compared with STZ). GSH=glutathione; PC=protein carbonyls; STZ=streptozotocin 45mg/kg bodyweight; TAU1=taurine supplementation 0.5g/kg bodyweight; TAU2=taurine supplementation 1g/kg bodyweight; TSH=total thiols. Reproductive BioMedicine Online 2012 24, 558-566DOI: (10.1016/j.rbmo.2012.01.016) Copyright © 2012 Reproductive Healthcare Ltd. Terms and Conditions

Figure 3 Effect of oral taurine supplementation on gestation days 5–12 on antioxidant enzyme activities in embryos of pregnant rats rendered diabetic by an acute dose of streptozotocin on gestation day 4. Values are mean±SD (18 embryos per group; two embryos each from six dams). Data were analysed by two-way ANOVA. aP<0.05 (compared with control); bP<0.05 (compared with STZ). CAT=catalase; GPX=glutathione peroxidase; GR=glutathione reductase; GST=glutathione transferase; SOD=superoxide dismutase; STZ=streptozotocin 45mg/kg bodyweight; TAU1=taurine supplementation 0.5g/kg bodyweight; TAU2=taurine supplementation 1g/kg bodyweight. Reproductive BioMedicine Online 2012 24, 558-566DOI: (10.1016/j.rbmo.2012.01.016) Copyright © 2012 Reproductive Healthcare Ltd. Terms and Conditions