Implication of HLA-G 5′ upstream regulatory region polymorphisms in idiopathic recurrent spontaneous abortions  Divya Agrawal, Swayam Prakash, Maneesh Kumar Misra, Shubha R. Phadke, Suraksha Agrawal  Reproductive BioMedicine Online  Volume 30, Issue 1, Pages 82-91 (January 2015) DOI: 10.1016/j.rbmo.2014.09.015 Copyright © 2014 Reproductive Healthcare Ltd. Terms and Conditions

Figure 1 HLA-G 5′- upstream regulatory region single nucleotide polymorphism (minor allele frequency ≥ 2%) and 14bp insertion-deletion polymorphism in exon-8 of 3′-UTR define nine unique haplotype among North Indian population. The shaded cells (grey colour) represent minor allele, whereas cells with no-shading represent major allele. Reproductive BioMedicine Online 2015 30, 82-91DOI: (10.1016/j.rbmo.2014.09.015) Copyright © 2014 Reproductive Healthcare Ltd. Terms and Conditions

Figure 2 Linkage disequilibrium between pairs of 5′- upstream regulatory region single nucleotide polymorphism and 14bp insertion–deletion polymorphism in the HLA-G for combined cases of idiopathic recurrent spontaneous abortion and control women. The image was generated using HAPLOVIEW (version 4.2) programme using single nucleotide polymorphism with minor allele frequencies greater than 2%. Colour interpretations: dark red: strong linkage disequilibrium (linkage disequilibrium ≥ 2, D′ = 1); pink: moderate linkage disequilibrium (linkage disequilibrium ≥ 2, D′ < 1); and white: no linkage disequilibrium (linkage disequilibrium < 2, D′ < 1). LOD: log of the odds; D′: pairwise correlation between single nucleotide polymorphisms. Reproductive BioMedicine Online 2015 30, 82-91DOI: (10.1016/j.rbmo.2014.09.015) Copyright © 2014 Reproductive Healthcare Ltd. Terms and Conditions