Status of Donor-Recipient HLA Class I Ligands and Not the KIR Genotype Is Predictive for the Outcome of Unrelated Hematopoietic Stem Cell Transplantation.

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Status of Donor-Recipient HLA Class I Ligands and Not the KIR Genotype Is Predictive for the Outcome of Unrelated Hematopoietic Stem Cell Transplantation in Beta- Thalassemia Patients Giorgio La Nasa, Roberto Littera, Franco Locatelli, Claudio Giardini, Arianna Ventrella, Marina Mulargia, Adriana Vacca, Nicola Orrù, Sandro Orrù, Eugenia Piras, Giada Giustolisi, Daniela Lisini, Sonia Nesci, Giovanni Caocci, Carlo Carcassi Biology of Blood and Marrow Transplantation Volume 13, Issue 11, Pages 1358-1368 (November 2007) DOI: 10.1016/j.bbmt.2007.07.011 Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Kaplan-Meier probabilities of overall survival, thalassemia-free survival and cumulative incidence of mortality and rejection in 45 thalassemia patients transplanted from an unrelated donor. Biology of Blood and Marrow Transplantation 2007 13, 1358-1368DOI: (10.1016/j.bbmt.2007.07.011) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Influence of heterozygosity for the HLA-Cw ligand groups 1 and 2 (C1/C2) on the incidence of grade II-IV aGVHD in 45 thalassemia patients transplanted from an unrelated donor. (C1/C2 patients = 22, events = 10; C1/C1 patients = 9, events = 0; C2/C2 patients = 14, events = 2). Biology of Blood and Marrow Transplantation 2007 13, 1358-1368DOI: (10.1016/j.bbmt.2007.07.011) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 Influence of homozygosity for the HLA-Cw ligand groups (C1/C1 or C2/C2) on the cumulative incidence of rejection in 45 thalassemia patients transplanted from an unrelated donor. (C1/C1 patients = 9, events = 3; C2/C2 patients = 14, events = 4; C1/C2 patients = 22, events = 0). Biology of Blood and Marrow Transplantation 2007 13, 1358-1368DOI: (10.1016/j.bbmt.2007.07.011) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 4 Comparison of the probabilities of thalassemia-free survival (TFS) between 22 C1/C2 heterozygotes (events = 18) and 23 C1/C1 or C2/C2 homozygotes (C1/C1 patients = 9, events 6; C2/C2 patients = 14, events = 8). Biology of Blood and Marrow Transplantation 2007 13, 1358-1368DOI: (10.1016/j.bbmt.2007.07.011) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 5 Impact of the presence of the HLA-A11 KIR antigen on the incidence of grade II-IV aGVHD in 45 thalassemia patients transplanted from an unrelated donor. (HLA-A11 positive patients = 11, events = 0; HLA-A11 negative patients = 34, events 12). Biology of Blood and Marrow Transplantation 2007 13, 1358-1368DOI: (10.1016/j.bbmt.2007.07.011) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions