Transfusion-Related Acute Lung Injury

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Presentation transcript:

Transfusion-Related Acute Lung Injury Ognjen Gajic, MD, MSc, S. Breanndan Moore, MD, FRCPI Mayo Clinic Proceedings Volume 80, Issue 6, Pages 766-770 (June 2005) DOI: 10.4065/80.6.766 Copyright © 2005 Mayo Foundation for Medical Education and Research Terms and Conditions

FIGURE 1 Pathogenesis of transfusion-related acute lung injury. The presence of antileukocyte antibodies and/or biologically active lipids from cell membrane fragments in donor blood triggers an inflammatory response, granulocyte activation, and degranulation and injury to the alveolar-capillary membrane. Activated macrophages secrete inflammatory cytokines that further perpetuate the inflammatory reaction. C = complement; HLA = human leukocyte antigen; IL = interleukin; LPS = lysophosphatidil choline; PAF = platelet activating factor; TNF = tumor necrosis factor; 5b, NA, NB = neutrophil antigens. Mayo Clinic Proceedings 2005 80, 766-770DOI: (10.4065/80.6.766) Copyright © 2005 Mayo Foundation for Medical Education and Research Terms and Conditions