Volume 144, Issue 4, Pages e2 (April 2013)

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Volume 144, Issue 4, Pages 726-735.e2 (April 2013) Levels of Antibodies Against Tissue Transglutaminase During Pregnancy Are Associated With Reduced Fetal Weight and Birth Weight Jessica C. Kiefte–de Jong, Vincent W.V. Jaddoe, André G. Uitterlinden, Eric A.P. Steegers, Sten P. Willemsen, Albert Hofman, Herbert Hooijkaas, Henriette A. Moll Gastroenterology Volume 144, Issue 4, Pages 726-735.e2 (April 2013) DOI: 10.1053/j.gastro.2013.01.003 Copyright © 2013 AGA Institute Terms and Conditions

Figure 1 Simplified conceptual framework for the association between celiac disease autoantibodies and fetal growth. Gastroenterology 2013 144, 726-735.e2DOI: (10.1053/j.gastro.2013.01.003) Copyright © 2013 AGA Institute Terms and Conditions

Figure 2 Flowchart of the study. Gastroenterology 2013 144, 726-735.e2DOI: (10.1053/j.gastro.2013.01.003) Copyright © 2013 AGA Institute Terms and Conditions

Figure 3 Carriers of the HLA-DQ2.5, -DQ2.2, or -DQ8 molecule according to anti-tTG levels. Gastroenterology 2013 144, 726-735.e2DOI: (10.1053/j.gastro.2013.01.003) Copyright © 2013 AGA Institute Terms and Conditions

Figure 4 Difference in fetal growth SD score during pregnancy for intermediate and positive anti-tTG levels relative to mothers with negative anti-tTG levels (n = 7046; P = .02 for overall difference in growth curves between positive and intermediate levels relative to negative anti-tTG levels assessed by the F test; shaded area represents 95% CI; dashed line represents the reference group: negative anti-tTG). Gastroenterology 2013 144, 726-735.e2DOI: (10.1053/j.gastro.2013.01.003) Copyright © 2013 AGA Institute Terms and Conditions

Supplementary Figure 1 Fractional polynomials model between anti-tTG titers and birth weight SD score (Y = B0 + B1 * 1/√anti-tTG + B2 * ln(anti-tTG) * Ln(anti-tTG); P < .01). Gastroenterology 2013 144, 726-735.e2DOI: (10.1053/j.gastro.2013.01.003) Copyright © 2013 AGA Institute Terms and Conditions

Supplementary Figure 2 Maternal nutritional status as explanation for the association between anti-tTG levels and birth weight SD score (N = 7046; *P < .05; **P = .05 for difference in mean birth weight SD score relative to negative anti-tTG levels). Gastroenterology 2013 144, 726-735.e2DOI: (10.1053/j.gastro.2013.01.003) Copyright © 2013 AGA Institute Terms and Conditions

Supplementary Figure 3 Maternal nutritional status as explanation for the association between anti-tTG levels and placental weight (N = 7046; *P < .05, **P = .10 for difference in placenta weight relative to negative anti-tTG levels). Gastroenterology 2013 144, 726-735.e2DOI: (10.1053/j.gastro.2013.01.003) Copyright © 2013 AGA Institute Terms and Conditions