The role of CD28-B7 costimulation in allergen-induced cytokine release by bronchial mucosa from patients with moderately severe asthma James L. Lordan,

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Presentation transcript:

The role of CD28-B7 costimulation in allergen-induced cytokine release by bronchial mucosa from patients with moderately severe asthma James L. Lordan, MD, Donna E. Davies, PhD, Susan J. Wilson, PhD, Gordon Dent, PhD, Andrea Corkhill, BSc, Zeina Jaffar, PhD, Kevan Roberts, PhD, Ratko Djukanović, MD, Stephen T. Holgate, FRCP Journal of Allergy and Clinical Immunology Volume 108, Issue 6, Pages 976-981 (December 2001) DOI: 10.1067/mai.2001.119740 Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 1 Cytokine protein concentration and mRNA gene expression in bronchial explant cultures of subjects with moderately severe asthma after culture in medium alone or after ex vivo stimulation with D pteronyssinus (Der p) allergen extract (5000 SQU/mL). A , IL-5 protein concentration (n = 15); B , IL-5 mRNA (n = 6); C , IL-13 protein concentration (n = 9); D , IL-13 mRNA (n = 6); E , GM-CSF protein concentration (n = 12); F , GM-CSF mRNA (n = 6). NS , Not significant. Journal of Allergy and Clinical Immunology 2001 108, 976-981DOI: (10.1067/mai.2001.119740) Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 2 Cytokine protein concentration and mRNA levels in bronchial explants of subjects with moderately severe asthma after culture in the presence of D pteronyssinus (Der p) allergen extract (5000 SQU/mL) in the absence or presence of CTLA-4Ig (25 μg/mL). A , IL-5 protein concentration (n = 12); B , IL-5 mRNA (n = 5); C , IL-13 protein concentration (n = 9); D , IL-13 mRNA (n = 6); E , GM-CSF protein concentration (n =11); F , GM-CSF mRNA (n = 6). NS , Not significant. Journal of Allergy and Clinical Immunology 2001 108, 976-981DOI: (10.1067/mai.2001.119740) Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 3 Cytokine protein concentration in PBMC cultures from subjects with moderately severe asthma after culture in either medium alone or house dust mite allergen extract D pteronyssinus (Der p ; 5000 SQU/mL) in the absence or presence of the fusion protein CTLA-4Ig. A and B , IL-5 protein concentration (n = 11); C and D , IL-13 protein concentration (n = 9); E and F , GM-CSF protein concentration (n = 12). Journal of Allergy and Clinical Immunology 2001 108, 976-981DOI: (10.1067/mai.2001.119740) Copyright © 2001 Mosby, Inc. Terms and Conditions