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Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2016.147 Figure 1 Origin, distribution and migration of human dendritic cell subsets Figure 1 | Origin, distribution and migration of human dendritic cell subsets. Human dendritic cells (DCs) arise from CD34+ haematopoietic stem cells (HSCs) of the bone marrow. CD34+ HSCs differentiate into monocyte-DC progenitors (MDPs), which in turn give rise to monocytes and common DC progenitors (CDPs). CDPs differentiate into plasmacytoid DCs (pDCs) and a conventional DC precursor (pre-cDC) that produces CD1c+ DCs and CD141+ DCs132,133. In normal conditions, DC subsets patrol continuously in peripheral tissues, sense environmental factors, pick up proteins and dying cells and migrate from tissues to draining lymph nodes. Inflammatory DCs (infDCs) differentiate separately from monocytes in response to inflammatory environment. Coutant, F. & Miossec, P. (2016) Altered dendritic cell functions in autoimmune diseases: distinct and overlapping profiles Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2016.147