Figure 2 Immunohistological detection of EBV latent and early lytic proteins in MS and control brains Immunohistological detection of EBV latent and early.

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Figure 2 Immunohistological detection of EBV latent and early lytic proteins in MS and control brains Immunohistological detection of EBV latent and early lytic proteins in MS and control brains CD20+ B lymphocytes (A–C) and CD138+ plasma cells (black arrowheads) (D–F) in the parenchyma and vasculature in a chronic active plaque (CAP) (A and D), in a chronic plaque (CP) (B and E), and in the vasculature of a healthy control brain sample (C and F). Percentage of CAP, CP, and control brain samples expressing CD138 protein detectable by immunohistochemistry are shown (M). We observed latent membrane protein-1 (LMP-1) expression (red arrowheads) in CAP, CP, and control brain samples (G–I). Percentage of CAP, CP, and control brain samples expressing LMP-1 protein detectable by immunohistochemistry are shown (N). Cells expressing LMP-1 (red arrowheads) were found in the vasculature of CAPs (G) and control brains (I), and within the parenchyma in a CP (H). The expression of the viral immediate-early protein BZLF1 was not observed in a CAP (J) and was observed in and around the vasculature in tissue from a CP (red arrowheads) (K). BZLF1 was also observed to a lesser extent in healthy controls (red arrowheads) (L). Percentage of CAP, CP, and control brain samples expressing BZLF1 protein detectable by immunohistochemistry are shown (O). Scale bar = 50 μm. Pictures are representative of analysis from 17 MS samples and 9 healthy controls. EBV = Epstein-Barr virus. Monica A. Moreno et al. Neurol Neuroimmunol Neuroinflamm 2018;5:e466 Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.