Tana L. Repella, Elise Manalo, Gregory Landry, Cherrie Abraham, Lynn Y

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Presentation transcript:

PC218 Cellular Effects of Tobacco Smoke Exposure in the Thoracic and Abdominal Aorta Tana L. Repella, Elise Manalo, Gregory Landry, Cherrie Abraham, Lynn Y. Sakai, Gregory Moneta, Amir Azarbal Journal of Vascular Surgery Volume 65, Issue 6, Pages 197S-198S (June 2017) DOI: 10.1016/j.jvs.2017.03.374 Copyright © 2017 Terms and Conditions

Fig 1 Treatment of wild-type mice with solubilized tobacco smoke results in elastin breaks in the aorta without a cellular infiltrate. These are representative images of (A) abdominal aorta of mice treated with phosphate-buffed saline, (B and C) abdominal aorta of mice treated with solubilized smoke solution via a subcutaneous osmotic pump, and (D) abdominal aorta of mice treated with solubilized smoke solution via a peritoneal osmotic pump. The arrows indicate areas of elastin breaks. Journal of Vascular Surgery 2017 65, 197S-198SDOI: (10.1016/j.jvs.2017.03.374) Copyright © 2017 Terms and Conditions

Fig 2 Treatment of hyperlipidemic mice with solubilized tobacco smoke results in plaque formation. These are representative images of (A) abdominal aorta of hyperlipidemic mice treated with phosphate-buffed saline, (B) thoracic aorta, or (C) abdominal aorta of hyperlipidemic mice treated with solubilized smoke solution via a subcutaneous osmotic pump, and (D) abdominal aorta of hyperlipidemic mice treated with solubilized smoke solution via a peritoneal osmotic pump. Journal of Vascular Surgery 2017 65, 197S-198SDOI: (10.1016/j.jvs.2017.03.374) Copyright © 2017 Terms and Conditions