Abilities of C. muridarum with or without mutations in tc0668 and/or tc0237 to ascend to the upper genital tract and spread to tissues outside the genital.

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Abilities of C. muridarum with or without mutations in tc0668 and/or tc0237 to ascend to the upper genital tract and spread to tissues outside the genital tract following intravaginal inoculation. Abilities of C. muridarum with or without mutations in tc0668 and/or tc0237 to ascend to the upper genital tract and spread to tissues outside the genital tract following intravaginal inoculation. Wild-type G13.32.1 (n = 7; panel a) or mutant C. muridarum G40.50.2 (n = 5; panel b), G13.11.1 (n = 7; panel c), or G28.51.1 (n = 5; panel d) was intravaginally inoculated into female C3H/HeJ mice as described in the legend to Fig. 1. On day 14 after inoculation, mice were sacrificed for harvesting of genital tract tissues, which were divided into the vagina/cervix (VC), uterine horn (UH), and oviduct/ovary (OV), and GI tract tissues, which were divided into the stomach (ST), small intestine (SI), cecum (CE), colon (CO), rectum (RE), kidneys (KD), liver (LI), spleen (SP), lungs (LU), and heart (HE), as displayed on the x axis, for measurement of live organisms. Vaginal swabs taken prior to mouse sacrifice and VC samples were designated the lower genital tract (LGT), while UH and OV samples were designated the upper genital tract (UGT). Live-organism titers, expressed as log10 IFU counts per tissue sample, are displayed on the y axis. The hydrosalpinx data displayed in the last column for analysis are from Fig. 1. IFU counts from each tissue type of mutant-infected mice were compared with those from the corresponding tissues of wild-type C. muridarum-infected mice. The IFU counts recovered from most tissues of the GI tract but not the non-GI tract tissues of mutant C. muridarum-infected mice were significantly lower than those recovered from wild-type C. muridarum-infected mice (*, P < 0.05; **, P < 0.01; a versus b, c, or d, Wilcoxon rank sum test). The IFU counts recovered from the GI tract tissues positively correlated with reduced hydrosalpinges in mutant C. muridarum-infected mice (Spearman rank-order correlation; the corresponding coefficients are shown at the top). Lili Shao et al. Infect. Immun. 2017; doi:10.1128/IAI.00321-17