Safety and efficacy of a heparin removal device: a prospective randomized preclinical outcomes study Joseph B Zwischenberger, MD, Weike Tao, MD, Donald.

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Presentation transcript:

Safety and efficacy of a heparin removal device: a prospective randomized preclinical outcomes study Joseph B Zwischenberger, MD, Weike Tao, MD, Donald J Deyo, DVM, Roger A Vertrees, PhD, Scott K Alpard, MD, Gerald Shulman, MD The Annals of Thoracic Surgery Volume 71, Issue 1, Pages 270-277 (January 2001) DOI: 10.1016/S0003-4975(00)01990-1

Fig 1 Changes in ACT during CPB and use of Protamine and the HRD in 60 kg (A), 80 kg (B), and 100 kg (C) weight subgroups (∗p values between groups at the end of HRD or protamine infusion were 0.117 in 60-kg, 0.03 in 80-kg, and 0.08 in 100-kg weight subgroups, respectively; Δp = 0.01 vs baseline). ACT in both groups returned to baseline 60 minutes after the HRD run. (POD = postoperative day.) The Annals of Thoracic Surgery 2001 71, 270-277DOI: (10.1016/S0003-4975(00)01990-1)

Fig 1 Changes in ACT during CPB and use of Protamine and the HRD in 60 kg (A), 80 kg (B), and 100 kg (C) weight subgroups (∗p values between groups at the end of HRD or protamine infusion were 0.117 in 60-kg, 0.03 in 80-kg, and 0.08 in 100-kg weight subgroups, respectively; Δp = 0.01 vs baseline). ACT in both groups returned to baseline 60 minutes after the HRD run. (POD = postoperative day.) The Annals of Thoracic Surgery 2001 71, 270-277DOI: (10.1016/S0003-4975(00)01990-1)

Fig 2 Plasma heparin concentration in HRD in 60-kg (A), 80-kg (B), and 100-kg (C) weight subgroups (∗p values between groups at the end of HRD or protamine infusion were 0.080 in 60-kg, 0.225 in 80-kg, and 0.090 in 100-kg weight subgroups, respectively, Δp = 0.01 vs baseline). Heparin concentrations in both groups returned to baseline 60 minutes after the HRD run. The Annals of Thoracic Surgery 2001 71, 270-277DOI: (10.1016/S0003-4975(00)01990-1)

Fig 2 Plasma heparin concentration in HRD in 60-kg (A), 80-kg (B), and 100-kg (C) weight subgroups (∗p values between groups at the end of HRD or protamine infusion were 0.080 in 60-kg, 0.225 in 80-kg, and 0.090 in 100-kg weight subgroups, respectively, Δp = 0.01 vs baseline). Heparin concentrations in both groups returned to baseline 60 minutes after the HRD run. The Annals of Thoracic Surgery 2001 71, 270-277DOI: (10.1016/S0003-4975(00)01990-1)

Fig 3 ATIII consumption pattern was not statistically different between groups throughout the study (Δp = 0.01 vs baseline). (POD = postoperative day.) The Annals of Thoracic Surgery 2001 71, 270-277DOI: (10.1016/S0003-4975(00)01990-1)

Fig 4 Platelet count was similar in both groups during CPB, and remained above baseline through postoperative day 3 (∗p = 0.05 between groups; Δp = 0.01 vs baseline). (POD = postoperative day.) The Annals of Thoracic Surgery 2001 71, 270-277DOI: (10.1016/S0003-4975(00)01990-1)

Fig 5 TEG index was not significantly different between the HRD and Protamine groups throughout the study. (POD = postoperative day.) The Annals of Thoracic Surgery 2001 71, 270-277DOI: (10.1016/S0003-4975(00)01990-1)

Fig 6 Percent activated C3 was not significantly different between the HRD and Protamine groups throughout the study. (POD = postoperative day.) The Annals of Thoracic Surgery 2001 71, 270-277DOI: (10.1016/S0003-4975(00)01990-1)