SRIA Roadmap 2019-2023 Jonathan Pearce Management Board Meeting, 2-3 April 2019, Basel SRIA Roadmap 2019-2023 Jonathan Pearce

SRIA Roadmap Procedure December 2018 SRIA prioritisation workshop February 2019 SAB feedback on prioritised topics MB feedback on prioritised topics/Ranking March 2019 Update of prioritised topics based on SAB and MB feedback April 2019 Finalise actions and draft roadmap May 2019 Publish roadmap

Funding mechanisms Research Calls Network Calls Workshops Out of the box ideas

JPIAMR Calls 2014-2019 JPIAMR Past actions Year Funding scheme Call Name Priority topics Investment (M €) 2014 Projects InnovaResistance Therapeutics 8.1 2015 Repurposing Neglected Antibiotics 4.5 2016 Transmission and Selection of Resistance in Humans, Animals, and the Environment (ERAnet Cofund) Transmission (One Health) 28.2 Networks AMR Networks All 0.65 2017 Comparison of prevention, control and intervention strategies for AMR infections through multidisciplinary studies, including One Health approaches Interventions (One Health) 11.5 2018 Therapeutics: New targets, compounds and tools 11.8 Surveillance 0.6 Building the Foundation of the JPIAMR Virtual Research Institute 0.5 2019 Development of diagnostic and surveillance tools, technologies and methods to detect antimicrobial resistance (AMR) Diagnostics Approx 18M Total 65.85

JPIAMR Workshops 2015-2019 JPIAMR Past actions Year Workshops 2015 Diagnostics Transmission dynamics intergovernmental 2016 New frontiers in AMR research Transatlantic collaboration on clinical trials The interplay between AMR surveillance and science 2017 Early discovery of new antibiotics Environmental dimensions of AMR JPIAMR Virtual Research Institute 2018 JPIAMR Funded Networks workshop 2019 Biocom AMR meeting (Industry) VRI Network Start-up Surveillance Network Start-up

JPIAMR Calls 2019-2023 JPIAMR Planned actions Year Funding scheme Call Name Priority topics Investment (M €) 2020 ERA Net ERAnet Emerging Pollutants and Pathogens 2019 1st calls Environment Transmission   2021 JPIAMR ACTION: AntimiCrobial Transmission InterventiONs Intervention ERAnet Emerging Pollutants and Pathogens 2019

JPIAMR Workshops 2019-2023 JPIAMR Planned actions Year Workshops 2019 Globalisation LAC Globalisation Eastern Europe AMR Funders Globalisation Asia 2020 VRI Network Final Surveillance Network Final

ERA-Net Aquatic Pollutants Research Call, Year: 2020 ERA-Net Aquatic Pollutants To fill existing key knowledge gaps regarding the environmental behaviour of new and emerging pollutants as well as pathogens in inland waters and the marine environment, and their impacts on ecosystems and human health Collaboration of the three JPIs on Water, Oceans and Antimicrobial Resistance (AMR) The AquaticPollutants proposal responds to the Horizon 2020 (H2020) Societal Challenge 5: Risks posed to human health and the environment by pollutants and pathogens present in water resources No of funders = 32 No. countries participating = 24 No. JPIAMR countries participating = 18

ERA-Net Transmission/Interventions Research Call, Year: 2021 ERA-Net Transmission/Interventions One Health interventions to prevent or reduce the development and transmission of antimicrobial resistance (AMR) General focus of the call: Interventions and Transmission Societal Challenge 1: Health, demographic change and wellbeing

Proposed JPIAMR SRIA Roadmap Topics 2019-2023 Management Board Discussion

Ranking 1 = low priority 2 = medium priority 3 = high priority

Link to AMR drug development hub Research Call, Year: 2022 THERAPEUTICS Ranking: 2.6 Optimising existing drugs or drug combinations for the treatment of infections and/or prevention of the emergence/spread of resistance caused by priority pathogens on the WHO and OIE lists, including and up to preclinical development Follows on from the 2nd JPIAMR Joint Call: Antimicrobial Resistance through the JPIAMR (projects funded 2016-2018) Could involve IMI Link to AMR drug development hub

Include fungal research Research Call, Year: 2023 ALL PILLARS Ranking: 3 Development of innovative, digital technologies for collection of microbiological, epidemiological, genetic, antibiotic and surveillance data for detection of transmission and surveillance of AMR in One Health settings Follow up of 2019 Joint Research Call on Diagnostics and Surveillance (projects funded 2020-2023) Include fungal research

Include fungal research Workshop, Year: XXXX SURVEILLANCE Network Call, Year: XXXX SURVEILLANCE Ranking: 2 Workshop: Harmonisation and technical validation of diagnostic tools bringing together researchers, industry, policymakers, regulators, insurance providers and funders Network Call: Multidisciplinary networks to address the harmonisation and technical validation of diagnostic tools Follow up of 2018 Network Call on Diagnostics and Surveillance (projects funded 2020- 2023) Include fungal research The ValueDx project has just started. This workshop could be organised jointly with ValueDx.

Workshop/Network Call, Year: XXXX THERAPEUTICS Ranking WS: 1.8 Ranking NC: 1.8 Workshop: Linking the global users of therapeutics and non-antibiotic therapies to identify new and alternative methods to fight infections and AMR Network Call: Global capacity building programmes in the area of early drug discovery of new targets, compounds and alternatives addressing pathogens on the WHO list of priority pathogens

Network Call, Year: XXXX ENVIRONMENT Ranking: 2 Identifying and developing best practices in innovative technological, policy, social, economic and regulatory approaches to mitigate the transmission of antibiotic resistant organisms, genetic elements and residues to, from and within the environment

Network Call, Year: XXXX TRANSMISSION Ranking: 2 Research methodologies to better define and quantify transmission routes of antimicrobial resistant organisms and mobile genetic elements to identify knowledge gaps in a One Health context

Workshop, Year: XXXX SURVEILLANCE Research Call, Year: XXXX SURVEILLANCE Ranking WS: 1.8 Ranking RC: 1.8 Workshop: Development of a globally integrated One Health surveillance system of antibiotic resistant genes and bacteria, and antibiotic usage with the goal of inter-sectoral coordination including the healthcare setting and community Research Call: Development of a globally integrated One Health surveillance system of antibiotic resistant bacteria and antibiotic usage

Network Call, Year: XXXX ENVIRONMENT Not ranked Collection of robust quantitative and qualitative data to develop risk prediction models

Network Call, Year: XXXX INTERVENTIONS Not ranked Building bridges between One Health areas to develop guidance and shared measures and standards to assess and implement interventions

Include the environmental impact of animal husbandry Workshop, Year: XXXX INTERVENTIONS TRANSMISSION Ranking: 1.7 Harmonisation of non-antibiotic approaches and strategies to replace, control or minimise the use of antibiotics in early life animal husbandry Should be followed by a research call to have the impact this topic requires Introduce a working group with a focus to identify best practises in this field Include the environmental impact of animal husbandry Should be opened to southern partners Question: should it be followed by a network call? Then a research call?

Network Call, Year: XXXX THERAPEUTICS Ranking: 1.6 Early drug discovery for capacity building in the discovery of new targets, compounds and alternatives There are also gaps in research on how to optimise and ease clinical trials for new therapeutics, we suggest to include these in this action. The risk of emergence of resistance to the new compounds alternatives should be considered.

Hackathon: Brainstorming session to find new ways to tackle AMR Out of the Box, Year: XXXX One Health New topic Proposed by SAB Hackathon: Brainstorming session to find new ways to tackle AMR Juniors (e.g. postdocs) will organise and invite ‘unusual suspects’ (a broader audience) Travel funds should be given to young people This could take the form of workshops to address certain questions This would enhance the generation of innovative ideas and solutions Could potentially lead to a future JPIAMR action, e.g. research call, network call, workshop