C. S. Winalski, M. D. , S. Shortkroff, Ph. D. , E. Schneider, Ph. D

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Presentation transcript:

Targeted dendrimer-based contrast agents for articular cartilage assessment by MR imaging C.S. Winalski, M.D., S. Shortkroff, Ph.D., E. Schneider, Ph.D., H. Yoshioka, M.D., R.V. Mulkern, Ph.D., G.M. Rosen, Ph.D. Osteoarthritis and Cartilage Volume 16, Issue 7, Pages 815-822 (July 2008) DOI: 10.1016/j.joca.2007.10.015 Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Structures of the simple, charged nitroxide and three of the dendrimer-linked nitroxides used in this study. [1] 3-trimethylaminomethyl-2,2,5,5-tetramethyl-1-pyrrolidinyloxyl iodide; [4] DAB-dendrimer-(NH-3-CO-PROXYL)16 with 16 nitroxides per molecule; [5] DAB-dendrimer-(NH-3-CO-PROXYL)32 with 32 nitroxides per molecule; and [6] PAMAM-(NH-3-CO-PROXYL)32 with 32 nitroxides per molecule. Osteoarthritis and Cartilage 2008 16, 815-822DOI: (10.1016/j.joca.2007.10.015) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 T1 calculated images obtained after immersion of patellar cartilage specimens in nitroxide [1], dendrimer-linked nitroxides [2–6], Gd–DTPA, or PBS bath solutions for 5 days. Cartilage T1 and R1dose values are reported below each map. Two specimens are shown for each bath solution in the orientation depicted in the specimen photo. Cartilage (C), bone, tendon (T), and bath are identified. Lower T1 values indicate a higher concentration of contrast agent. Osteoarthritis and Cartilage 2008 16, 815-822DOI: (10.1016/j.joca.2007.10.015) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Cartilage T1 and R1dose values of dendrimer-linked nitroxide [5] for the superficial one-quarter (surface) and central two-thirds (central) of the cartilage thickness after 5 and 10 days of equilibration in the contrast agent bath. Each T1 calculated image contains two patellar cartilage specimens oriented as in Fig. 2. The regions outlined in white on day 10 indicate the surface ROIs. Osteoarthritis and Cartilage 2008 16, 815-822DOI: (10.1016/j.joca.2007.10.015) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions