Zeljko S. Radic, MD, Martin K. O'Donohoe, MB, FRCSI, Lewis B

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Alterations in serotonergic receptor expression in experimental vein grafts Zeljko S. Radic, MD, Martin K. O'Donohoe, MB, FRCSI, Lewis B. Schwartz, MD, Adam D. Stein, MD, Eileen M. Mikat, PhD, Richard L. McCann, MD, Per-Otto Hagen, PhD Journal of Vascular Surgery Volume 14, Issue 1, Pages 40-47 (July 1991) DOI: 10.1016/0741-5214(91)90152-K Copyright © 1991 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Progressive intimal thickening of rabbit external jugular vein grafts harvested at 3 (A), 9 (B), 14 (C), and 28 (D) days. Sections are stained with Masson's trichrome and Verhoeff's elastic tissue stain. Significant intimal hyperplasia (IH) was observed as early as 1 week after implantation and continued to increase throughout the study period (original magnification × 66; L = lumen, I-M = intima + media, AD = adventitia). Journal of Vascular Surgery 1991 14, 40-47DOI: (10.1016/0741-5214(91)90152-K) Copyright © 1991 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Maximal tension to 5-HT (open circles) and % intimal area (open squares) in rabbit external jugular vein grafts harvested from 3 to 28 days. A total of 37 grafts were studied. Note the qualitative correlation between 5-HT response and percent intimal area. Numeric data are given in Tables I and II. Journal of Vascular Surgery 1991 14, 40-47DOI: (10.1016/0741-5214(91)90152-K) Copyright © 1991 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 3 5-HT dose-response curves of 11 rabbit external jugular vein grafts explanted after 9 days. ED50 progressively increased with increasing doses of ketanserin. Numeric data and statistical analysis are given in Table III. Journal of Vascular Surgery 1991 14, 40-47DOI: (10.1016/0741-5214(91)90152-K) Copyright © 1991 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 4 Response of precontracted rabbit external jugular vein to 5-HT. Addition of 5-HT to control veins (■) resulted in dose-dependent relaxation with maximum of 49% ± 10% at 1.7 × 10−7 mol/L. Incubation with ketanserin (▴) did not affect relaxation, whereas incubation with methiothepin (▾) completely abolished the relaxation response. Journal of Vascular Surgery 1991 14, 40-47DOI: (10.1016/0741-5214(91)90152-K) Copyright © 1991 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 5 Response of precontracted vein graft to 5-HT. Addition of 5-HT (closed squares) resulted in dose-dependent contraction with a maximum of 322% ± 33% at 10−4 mol/L Incubation with 10−6 mol/L ketanserin (closed triangle) resulted in a significant increase in ED50 (control 9.75 ± 1.5 × 10−7 mol/L vs ketanserin 1 1 ± 0.2 × 10−4 mol/L, p < 0.002). Journal of Vascular Surgery 1991 14, 40-47DOI: (10.1016/0741-5214(91)90152-K) Copyright © 1991 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions