Zheng Liu, MD, Jean Kim, MD, PhD, Joseph P

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Presentation transcript:

Gene expression profiles in human nasal polyp tissues studied by means of DNA microarray Zheng Liu, MD, Jean Kim, MD, PhD, Joseph P. Sypek, PhD, I-Ming Wang, PhD, Heidi Horton, Frank G. Oppenheim, DMD, PhD, Bruce S. Bochner, MD Journal of Allergy and Clinical Immunology Volume 114, Issue 4, Pages 783-790 (October 2004) DOI: 10.1016/j.jaci.2004.04.052 Copyright © 2004 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 1 Representative photomicrographs of sinus tissue sections showing immunohistochemical staining. A, Many CC10-positive cells in the epithelium of normal sinus mucosa. B, Few CC10-positive cells in the epithelium of NP tissues. C, CC10 and PAS double staining of normal sinus mucosa. Red arrowhead, CC10 and PAS double-positive cells; black arrowhead, CC10 single-positive cell. D, Statherin-positive glands in normal sinus mucosa. E, Statherin-positive glands in NP tissues. F, Few PIP-positive glands in normal sinus mucosa. G, Numerous PIP-positive glands in NP tissues. H, No lactoferrin staining in normal sinus mucosa. I, Many lactoferrin-positive glands in NP tissues. J, No DMBT1 staining in the gland of normal sinus mucosa. K, DMBT1 staining in the gland of NP mucosa. Original magnification: Fig 1, A-C, 400×; Fig 1, D-K, 200×. Journal of Allergy and Clinical Immunology 2004 114, 783-790DOI: (10.1016/j.jaci.2004.04.052) Copyright © 2004 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 2 Immunohistochemical analysis of the number of CC10-positive cells in normal sinus mucosal tissues (n=4, 2 sphenoid sinus mucosa and 2 ethmoid sinus mucosa) and NP tissues (n=13). NP tissues show reduced staining. Similar decreases are seen in both edematous-type (n=7) and glandular-type (n=6) nasal polyps. ∗P < .05 compared with normal sinus mucosa. Journal of Allergy and Clinical Immunology 2004 114, 783-790DOI: (10.1016/j.jaci.2004.04.052) Copyright © 2004 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 3 Immunohistochemical analysis of the number of statherin-, PIP-, lactoferrin-, DMBT1-positive glands in normal sinus mucosal (n=3, 1 sphenoid mucosa and 2 ethmoid mucosa) and NP tissues (n=10). Edematous-type polyps (n=5) show reduced staining, whereas the glandular-type polyps (n=5) show increased staining. ∗P < .05 compared with normal sinus mucosa; #P < .05 and ##P < .01 for glandular-type compared with edematous-type NP. Journal of Allergy and Clinical Immunology 2004 114, 783-790DOI: (10.1016/j.jaci.2004.04.052) Copyright © 2004 American Academy of Allergy, Asthma and Immunology Terms and Conditions