G. Blumenkrantz, B. S. , R. Stahl, M. D. , J. Carballido-Gamio, Ph. D

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Presentation transcript:

The feasibility of characterizing the spatial distribution of cartilage T2 using texture analysis  G. Blumenkrantz, B.S., R. Stahl, M.D., J. Carballido-Gamio, Ph.D., S. Zhao, Ph.D., Y. Lu, Ph.D., T. Munoz, M.D., M.-P. Hellio Le Graverand-Gastineau, M.D., Ph.D., S.K. Jain, M.D., T.M. Link, M.D., S. Majumdar, Ph.D.  Osteoarthritis and Cartilage  Volume 16, Issue 5, Pages 584-590 (May 2008) DOI: 10.1016/j.joca.2007.10.019 Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Representative T2 colormaps overlayed on T2-weighted images of an advanced OA patient (cartilage WORMS=5) (left), a mild OA patient (cartilage WORMS=1) (center), and a control subject (right). The entropy and ASM of cartilage T2 for the OA patients and control subject are listed in the table. The OA patients both have greater entropy and lower ASM than the control subject. Osteoarthritis and Cartilage 2008 16, 584-590DOI: (10.1016/j.joca.2007.10.019) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Entropy (top row) of cartilage T2 is greater in OA patients than in controls in all compartments combined, the lateral femur, and the medial tibia at 0° (top left) and 90° (top left). ASM (bottom row) of cartilage T2 greater in controls than in OA patients in all compartments combined, the lateral femur, and the medial tibia at 0° (bottom left) and 90° (bottom right). The ‘’ indicates a significant difference (P<0.05) between OA patients and controls. The ‘’ indicates P<0.10. Osteoarthritis and Cartilage 2008 16, 584-590DOI: (10.1016/j.joca.2007.10.019) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Increased (P<0.10) cartilage T2 ASM was evident in OA patients from baseline to 9 months. Decreased (P<0.10) cartilage T2 entropy was evident in OA patients from baseline to 9 months. Osteoarthritis and Cartilage 2008 16, 584-590DOI: (10.1016/j.joca.2007.10.019) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 Sagittal T2-weighted FSE images (top row) and cartilage T2 maps overlayed on T2-weighted FSE images (bottom row) of an OA patient at baseline and 9 months. At baseline, the cartilage signal at the posterior lateral tibia (arrow) is inhomogeneous (a) and at 9 months, an extensive cartilage defect with a more homogeneous signal has developed in the same area (arrow in [b]). An extensive adjacent bone marrow edema pattern is also evident. Visually, there is a decrease in the heterogeneity of T2 values from baseline to follow-up. Osteoarthritis and Cartilage 2008 16, 584-590DOI: (10.1016/j.joca.2007.10.019) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions