NRP1-expressing myeloid cells influence adipocyte hypertrophy, development of fatty liver, and CLSs. NRP1-expressing myeloid cells influence adipocyte.

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NRP1-expressing myeloid cells influence adipocyte hypertrophy, development of fatty liver, and CLSs. NRP1-expressing myeloid cells influence adipocyte hypertrophy, development of fatty liver, and CLSs. LysM-Cre-Nrp1+/+ (control) and LysM-Cre-Nrp1fl/fl mice were fed a HFD for 10 weeks. (A) Representative immunohistochemistry of perilipin-labeled VAT (left) (magnification, ×10; scale bar, 100 μm) and quantification of adipocyte density and size (right) (n = 3 to 4). (B) Liver photomicrographs (left) and liver weights (right, n = 8). (C) Oil Red O stain of liver sections (magnification, ×10; scale bar, 100 μm). (D) Immunohistochemistry of F4/80+-labeled VAT and quantification of CLSs (n = 13) (magnification, ×10; scale bars, 100 μm). *P < 0.05, **P < 0.01, ***P < 0.001, Student’s unpaired t test. Ariel Molly Wilson et al. Sci. Immunol. 2018;3:eaan4626 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works