Update on Graft versus Host Disease Anita C. Gilliam, M.D., Ph.D.  Journal of Investigative Dermatology  Volume 123, Issue 2, Pages 251-257 (August 2004) DOI: 10.1111/j.1523-1747.2004.23211.x Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 A, B: Acute cytotoxic GVHD in skin. In A (low power), an acute interface process involving epidermis is present, with "injury out of proportion to inflammation". In B, mononuclear cells tag early apoptotic keratinocytes mainly in the basilar keratinocyte area. C, D: Chronic lichenoid GVHD in mucosa. In C (low power) mucosa is thickened and hyperplastic, with a band-like lichenoid inflammatory infiltrate in submucosa. Some "sawtoothing" of the epithelium is present. In B (high power), the dramatic infiltration of lower epithelium by mononuclear cells is seen. E, F: Chronic sclerodermoid GVHD in skin. In E (low power), dense acellular collagen is present at all levels of dermis, but more prominently in upper dermis. In F (high power), the thick collagen bundles are more apparent. No dramatic interface changes are seen as in acute or chronic cytotoxic GVHD. Journal of Investigative Dermatology 2004 123, 251-257DOI: (10.1111/j.1523-1747.2004.23211.x) Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions