Angiogenesis and growth factor expression in a model of transmyocardial revascularization Marc P. Pelletier, MD, Adel Giaid, PhD, Sujith Sivaraman, BSc,

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Angiogenesis and growth factor expression in a model of transmyocardial revascularization Marc P. Pelletier, MD, Adel Giaid, PhD, Sujith Sivaraman, BSc, Julia Dorfman, MD, Carlos M. Li, MD, Anie Philip, PhD, Ray C.-J. Chiu, MD, PhD The Annals of Thoracic Surgery Volume 66, Issue 1, Pages 12-18 (July 1998) DOI: 10.1016/S0003-4975(98)00388-9

Fig 1 Light photomicrograph of cross-section of infarcted myocardium in the transmyocardial revascularization group. Multiple vacuolated circles surrounded by brownish-stained cells represent small vessels. Dense inflammatory tissue also is present. (Factor VIII staining [brown] and hematoxylin and eosin [blue]; ×250 before 54% reduction.) The Annals of Thoracic Surgery 1998 66, 12-18DOI: (10.1016/S0003-4975(98)00388-9)

Fig 2 Bar graph showing the vascular density in number of vessels per high-power field (HPF; ×250) in both the control (group I) and experimental groups (group II) at intervals of 1 to 8 weeks, along with the overall comparison of both groups (all subgroups from 1 to 8 weeks combined). (NS = not significant.) The Annals of Thoracic Surgery 1998 66, 12-18DOI: (10.1016/S0003-4975(98)00388-9)

Fig 3 Bar graph showing the area of staining to transforming growth factor-β (TGFβ) in square millimeters of staining per square millimeter of infarcted myocardium in both the control (group I) and experimental groups (group II) at intervals of 1 to 8 weeks. (∗p < 0.05.) The Annals of Thoracic Surgery 1998 66, 12-18DOI: (10.1016/S0003-4975(98)00388-9)

Fig 4 Light photomicrograph of cross-section of infarcted myocardium in the transmyocardial revascularization group. Brown staining represents transforming growth factor-β ligand expressed among a diffuse inflammatory background. (Hematoxylin and eosin; ×250 before 54% reduction.) The Annals of Thoracic Surgery 1998 66, 12-18DOI: (10.1016/S0003-4975(98)00388-9)

Fig 5 Bar graph showing the area of staining to transforming growth factor-β (TGFβ) in square millimeters of staining per square millimeter of noninfarcted myocardium in both the control (group I) and experimental groups (group II) at intervals of 1 to 8 weeks. No statistically significant difference is present. The Annals of Thoracic Surgery 1998 66, 12-18DOI: (10.1016/S0003-4975(98)00388-9)

Fig 6 Bar graph showing the area of staining to basic-fibroblast growth factor (bFGF) in square millimeters of staining per square millimeter of infarcted myocardium in both the control (group I) and experimental groups (group II) at intervals of 1 to 8 weeks. (∗p < 0.05.) The Annals of Thoracic Surgery 1998 66, 12-18DOI: (10.1016/S0003-4975(98)00388-9)

Fig 7 Bar graph showing the area of staining to vasoendothelial growth factor (VEGF) in square millimeters of staining per square millimeter of infarcted myocardium in both the control (group I) and experimental groups (group II) at intervals of 1 to 8 weeks. No significant difference is present. The Annals of Thoracic Surgery 1998 66, 12-18DOI: (10.1016/S0003-4975(98)00388-9)