Neesh Pannu, Braden Manns, Helen Lee, Marcello Tonelli

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Systematic review of the impact of N-acetylcysteine on contrast nephropathy Neesh Pannu, Braden Manns, Helen Lee, Marcello Tonelli Kidney International Volume 65, Issue 4, Pages 1366-1374 (April 2004) DOI: 10.1111/j.1523-1755.2004.00516.x Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 1 Funnel plot of effect size versus precision of effect size. The figure plots an index of effect size (ln relative risk) against its precision [standard error (SE) of ln relative risk]. There is an absence of small trials that found an increased incidence of contrast nephropathy associated with N-acetylcysteine (NAC). Kidney International 2004 65, 1366-1374DOI: (10.1111/j.1523-1755.2004.00516.x) Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 2 Relative risk of contrast nephropathy associated with NAC: All identified trials. Relative risk refers to the risk of contrast nephropathy in the N-acetylcysteine (NAC) group, compared with control. The squares represent the point estimate of relative risk for each study, and their size is proportional to their weight in the pooled estimate of relative risk (represented by the diamond). Bars indicate 95% CI. Q = 26.3, P = 0.02. Kidney International 2004 65, 1366-1374DOI: (10.1111/j.1523-1755.2004.00516.x) Copyright © 2004 International Society of Nephrology Terms and Conditions