Norman R. Harris, Rolando E. Rumbaut Pathophysiology

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Age-related responses of the microcirculation to ischemia-reperfusion and inflammation Norman R. Harris, Rolando E. Rumbaut Pathophysiology Volume 8, Issue 1, Pages 1-10 (August 2001) DOI: 10.1016/S0928-4680(01)00064-5

Fig. 1 Albumin leakage index in 2- and 20-month-old rats with or without injection of anti-neutrophil serum (ANS or control). Measurements were made during a baseline period and following 30 min of ischemia and 40 min of reperfusion. Data are given as means±SE. A portion of the data is from a recent study [50]: N=24 for young control rats; N=17 for old control rats; N=6 for the other two groups. *P<0.05 compared with baseline; †P<0.05 compared with control. Pathophysiology 2001 8, 1-10DOI: (10.1016/S0928-4680(01)00064-5)

Fig. 2 Leukocyte adherence in 2- and 20-month-old rats with or without injection of anti-neutrophil serum (ANS or control). Measurements were made during a baseline period and following 30 min of ischemia and 40 min of reperfusion. Data are given as means±SE. A portion of the data is from a recent study [50]: N=25 for young control rats; N=17 for old control rats; N=6 for the other two groups. *P<0.05 compared with baseline; †P<0.05 compared with control; ‡P<0.05 compared with young. Pathophysiology 2001 8, 1-10DOI: (10.1016/S0928-4680(01)00064-5)

Fig. 3 Circulating neutrophils (a) and mononuclear leukocytes (b) in 2- and 20-month-old rats with or without injection of anti-neutrophil serum (ANS or control). Measurements were made during a baseline period and following 30 min of ischemia and 40 min of reperfusion. Data are given as means±SE. A portion of the data is from a recent study [50]: N=25 for young control rats; N=14 for old control rats; N=6 for young ANS rats; N=5 for old ANS rats. *P<0.05 compared with baseline; †P<0.05 compared with control; ‡P<0.05 compared with young. Pathophysiology 2001 8, 1-10DOI: (10.1016/S0928-4680(01)00064-5)

Fig. 4 Oxidative stress (rhodamine 123 intensity) in tissue surrounding postcapillary venules in young and older rats exposed to either ischemia and reperfusion or a sham time control. Data are given as means±SE. The data are from a recent study [50]: N=5, 5, 7, and 10 rats in groups from left to right. ‡P<0.05 compared with young. Pathophysiology 2001 8, 1-10DOI: (10.1016/S0928-4680(01)00064-5)

Fig. 5 Venular shear rates in 2- and 20-month-old rats with or without injection of anti-neutrophil serum (ANS or control). Measurements were made during a baseline period and following 30 min of ischemia and 40 min of reperfusion. Data are given as means±SE. A portion of the data is from a recent study [50]: N=21 for young control rats; N=17 for old control rats; N=5 for young ANS rats; N=4 for old ANS rats. *P<0.05 compared with baseline; †P<0.05 compared with control; ‡P<0.05 compared with young. Pathophysiology 2001 8, 1-10DOI: (10.1016/S0928-4680(01)00064-5)

Fig. 6 Albumin leakage index in 2-month old (N=12) and 20-month old (N=9) rats before (baseline) and after 30 min of mesenteric superfusion of l-NAME. Data are given as means±SE. The data are from a recent study [50]. *P<0.05 compared with baseline. Pathophysiology 2001 8, 1-10DOI: (10.1016/S0928-4680(01)00064-5)