Neuronal ATM level is reduced in mouse models of AD

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Neuronal ATM level is reduced in mouse models of AD Neuronal ATM level is reduced in mouse models of AD. Sagittal brain sections from three AD mouse models and wild-type controls (age, 13-14 months) were double immunostained for HDAC4 (red) and Map2 (green). Neuronal ATM level is reduced in mouse models of AD. Sagittal brain sections from three AD mouse models and wild-type controls (age, 13-14 months) were double immunostained for HDAC4 (red) and Map2 (green). Scale bar, 50 μm. A–D, Wild-type mice (Wt; A), R1.40 APP transgenic mouse (B), PS/APP double-transgenic mouse (C), and 3xTg triple-transgenic mouse (D). E, Quantification of the percentage of neurons with HDAC4N found in the frontal cortex and hippocampus of each model examined. Difference determined by t test, *p < 0.05, **p < 0.01, ***p < 0.001 (n = 3-4). Xuting Shen et al. eneuro 2016;3:ENEURO.0124-15.2016 ©2016 by Society for Neuroscience