Rfu1: Stimulus for the Ubiquitin Economy

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Rfu1: Stimulus for the Ubiquitin Economy Dieter A. Wolf, Matthew D. Petroski Cell Volume 137, Issue 3, Pages 397-398 (May 2009) DOI: 10.1016/j.cell.2009.04.032 Copyright © 2009 Elsevier Inc. Terms and Conditions

Figure 1 Rfu1 in Ubiquitin Homeostasis Under normal conditions, Rfu1 inhibits the deubiquitinating (DUB) activity of Doa4 to promote an appropriate balance between monoubiquitin and polyubiquitin chains. In response to heat stress, Rfu1 is downregulated via posttranscriptional and posttranslational mechanisms, alleviating its inhibition of Doa4. This shifts the normal balance of ubiquitin toward monoubiquitin, thereby increasing the pool of monoubiquitin available for conjugation. Cell 2009 137, 397-398DOI: (10.1016/j.cell.2009.04.032) Copyright © 2009 Elsevier Inc. Terms and Conditions