Molecular Imaging in Gastrointestinal Disease Umar Mahmood, Michael B. Wallace  Gastroenterology  Volume 132, Issue 1, Pages 11-14 (January 2007) DOI: 10.1053/j.gastro.2006.12.013 Copyright © 2007 AGA Institute Terms and Conditions

Figure 1 Schematic diagram of probe activation. Fluorochromes are covalently coupled to a polylysine backbone. Because of the proximity of the fluorochromes, autoquenching occurs so that almost no fluorescent signal can be detected in the nonactivated state. After designated enzyme cleavage, fluorochromes are released from the carrier and become brightly fluorescent. Gastroenterology 2007 132, 11-14DOI: (10.1053/j.gastro.2006.12.013) Copyright © 2007 AGA Institute Terms and Conditions

Figure 2 Frames from a murine colonoscopy demonstrates 2 colonic adenocarcinomas that result in minimal anatomic distortion of the lumen (left), but which are readily apparent on simultaneously acquired false-colored NIR images (right). Gastroenterology 2007 132, 11-14DOI: (10.1053/j.gastro.2006.12.013) Copyright © 2007 AGA Institute Terms and Conditions