European Urology Oncology Predictive Role of Computed Tomography Texture Analysis in Patients with Metastatic Urothelial Cancer Treated with Programmed Death-1 and Programmed Death-ligand 1 Inhibitors  Francesco Alessandrino, Rahul Gujrathi, Amin H. Nassar, Arwa Alzaghal, Arvind Ravi, Bradley McGregor, Guru Sonpavde, Atul B. Shinagare  European Urology Oncology  DOI: 10.1016/j.euo.2019.02.002 Copyright © 2019 Terms and Conditions

Fig. 1 Localization of lesions analyzed at baseline and first follow-up CT. CT=computed tomography. European Urology Oncology DOI: (10.1016/j.euo.2019.02.002) Copyright © 2019 Terms and Conditions

Fig. 2 Region of interest contouring and texture analysis evaluation on first follow-up CT. Contrast-enhanced CT scans of the abdomen show contoured nodal lesions (A) in a patient with progression-free survival (PFS) <12mo and (B) in a patient with PFS >12mo. (C) Histogram analysis of the two lesions shows different shapes of the histogram and higher values of the lesion of patient A (blue line), reflecting higher mean and higher entropy. CT=computed tomography. European Urology Oncology DOI: (10.1016/j.euo.2019.02.002) Copyright © 2019 Terms and Conditions