BRC Science Highlight Yeast evolved for enhanced xylose utilization reveal interactions between cell signaling and Fe-S cluster biogenesis Objective Obtain.

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BRC Science Highlight Yeast evolved for enhanced xylose utilization reveal interactions between cell signaling and Fe-S cluster biogenesis Objective Obtain yeast strains that have enhanced xylose utilization and identify genetic determinants that contribute to the enhanced utilization Approach Saccharomyces cerevisiae was subjected to successive rounds of directed evolution, selecting for growth on xylose Whole genome sequencing of evolved strains identified causative mutations and systems-level proteomic and metabolomic changes in response to xylose were analyzed Notes: text Title again: Text 1-2 sentence summary? Result/Impacts Rapid xylose utilization was found to be dependent upon genetic interactions among four genes, uncovering a surprising connection between Fe-S cluster assembly and cell signaling that facilitates aerobic respiration and anaerobic fermentation of xylose Understanding how yeast cells adapt to non-preferential carbon sources uncovers potential genetic engineering strategies that can improve efficiency of biofuel production Sato, T. K. et al. Directed evolution reveals unexpected epistatic interactions that alter metabolic regulation and enable anaerobic xylose use by Saccharomyces cerevisiae. PLOS Genetics (2016) [DOI: 10.1371/journal.pgen.1006372] GLBRC October 2016

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