Immunosuppressive treatment of aortic allografts

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Presentation transcript:

Immunosuppressive treatment of aortic allografts Thomas Schmitz-Rixen, M.D. *, Joseph Megerman, Ph.D., Robert B. Colvin, M.D., Althea M. Williams, A.S., William M. Abbott, M.D. Journal of Vascular Surgery Volume 7, Issue 1, Pages 82-92 (January 1988) DOI: 10.1016/0741-5214(88)90381-3 Copyright © 1988 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Experimental design, including drug dosages and times of harvest. BN and L denote Brown-Norway and Lewis rats, respectively. Dosages are presented as average daily miligram per kilogram of body weight; see Table I for actual regimens. Each asterisk denotes harvest of a complete subgroup. Journal of Vascular Surgery 1988 7, 82-92DOI: (10.1016/0741-5214(88)90381-3) Copyright © 1988 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Effect of cyclosporine on diameter increase of aortic grafts. Groups A (♦) and B (♢) denote isograft and allograft controls, respectively (open symbols), and groups C (■), D (▴), and E(▾) denote increasing levels of average drug dose (closed symbols). Dashed line represents no change. DAta shown as mean ± standard error of the mean (SEM). Journal of Vascular Surgery 1988 7, 82-92DOI: (10.1016/0741-5214(88)90381-3) Copyright © 1988 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 3 Effect of cyclosporine on thickness of the intima and media. Groups and symbols are as defined in Fig. 2. Data shown as mean ± SEM. Journal of Vascular Surgery 1988 7, 82-92DOI: (10.1016/0741-5214(88)90381-3) Copyright © 1988 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 4 Effect of cyclosporine on cellular infiltration of the intima and adventitia. Groups and symbols are as defined in Fig. 2. Points represent mean of scores (from hematoxylin-eosin—stained micrographs) that were assigned as described in text. Journal of Vascular Surgery 1988 7, 82-92DOI: (10.1016/0741-5214(88)90381-3) Copyright © 1988 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 5 Micrographs of isograft (A) and untreated allograft (B) controls, and of treated allograft from group D (C), all at 100 days. Lumen is at top. (Elastic tissue (van Gieson) stain, magnification × 313.) In this and subsequent figures, the fields are aligned by the external elastica (bottom arrows); the internal elastica is also indicated (upper arrows). In the untreated allograft (B), the media has lost the normal population of smooth muscle cells and there is a mononuclear inflammatory infiltrate. Neither of these effects is evident in the allograft from a recipient treated with cyclosporine for the first 30 days (C). Journal of Vascular Surgery 1988 7, 82-92DOI: (10.1016/0741-5214(88)90381-3) Copyright © 1988 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 6 Samples equivalent to those in Fig. 4 at 100 days. Note severely thickened intima and thinned media in the untreated allograft (B), compared with the normal appearance of the isograft (A). Some disruption of elastic fibers has occurred in the media of an allograft from a rat treated with cyclosporine for the first 30 days (C). (Hematoxylin-eosin stain; original magnification ×313.) Journal of Vascular Surgery 1988 7, 82-92DOI: (10.1016/0741-5214(88)90381-3) Copyright © 1988 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 7 Samples equivalent to those in Fig. 4 at 30 days. A, Isograft. In untreated allograft (B), there is clear evidence of intimal thickening and mononuclear cell infiltration in the intima and adventitia (*). Intimal thickening has not yet occurred in the treated allograft (C), nor is there evidence of an inflammatory response. (Hematoxylin-eosin; original magnification × 313.) Journal of Vascular Surgery 1988 7, 82-92DOI: (10.1016/0741-5214(88)90381-3) Copyright © 1988 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 8 Correlation between diameter increase and medial thinning in aortic grafts. On the basis of individual points, the relationship is nonlinear (r = 0.65, p < 0.0001 for correlation, and for nonlinearity, p < 0.01); with subgroup means (±SEM), the relationship becomes linear (inset: r = 0.91, p < 0.001). Journal of Vascular Surgery 1988 7, 82-92DOI: (10.1016/0741-5214(88)90381-3) Copyright © 1988 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions